H1N1 flu

The vulnerability translated to substantial number of deaths, estimated to be between 2,500 and 6,100 according to the CDC. There is good news on the horizon, as week to week indicators show both a decline in national doctor visits for the flu and there has been a substantial decline n number of states reporting widespread H1N1 activity.

This may be sign of the H1N1 outbreak peak, a figure Art Reingold has been closely monitoring for the past few months. He'll be discussing the epidemiology of the pandemic and the controversy over the vaccine.

To learn more about the H1N1 virus, call: (800) CDC-INFO (800 232-4636) or visit the CDC's website.

H1N1 Update with Dr. Art Reingold
When: Wednesday, December 9th, 7-9 PM
Where: Cafe Valparaiso at La Pena Cultural Center
Cost: Free
Details: Experts are predicting a substantial resurgence of swine flu cases this coming winter. Art Reingold will provide an update concerning the global pandemic of novel H1N1(swine) influenza; the current state of affairs in the US and California; and options for prevention, including a pandemic influenza vaccine.

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The last time we reported on Swine flu, or 2009 H1N1 virus, the Centers for Disease Control and Prevention was considering whether or not to invest in a vaccine for the new influenza strain.

Now, after several delays, the first batches of vaccines — first, a nasal spray version, then an injectible vaccine — is due to hit hospitals and clinics across the country (and around the world) in the first weeks of October. It's up to each state to decide which groups to prioritize, but pregnant women, young children, and those with certain preexisting conditions such as asthma may be considered priorities. Over the following weeks, the flow of vaccines, produced at five different labs across the country, will steadily increase until, officials hope, any American who chooses to be vaccinated has access to a dose.

To learn more about where to get the vaccine, call: (800) CDC-INFO (800 232-4636) or visit www.cdc.gov/flu.

Here's another good resource for basic H1N1 vaccine info.

In this piece, we profile work taking place at the University of California, San Francisco's Viral Diagnostics and Discovery Center. This lab is home to the ViroChip – a powerful viral diagnostic tool that won its inventor, Joseph DeRisi, a MacArthur "Genius" Grant back in 2004. TheViroChip and other tools are critical to the fight against 2009 H1N1 . Among other things, they may be the first to alert us should the virus mutate into a form that's resistant to the leading antiviral drug, Tamiflu. (Several cases of Tamiflu-resistant 2009 H1N1 have already been reported, but so far they appear to be isolated incidents.)

They'll be looking out for another important mutation too: That's if 2009 H1N1 changes enough so that the current vaccine for it — the one coming out in October — no longer works. (This kind of subtle virus mutation is the reason we need new flu vaccines every year.) So far, this does not seem to be the case.

Listen to the Predicting Swine Flu radio report online.

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Animal viruses can be more deadly than their human
counterparts

Over those two years, at least three waves of flu struck killing over 600,000 people in the U.S. and a staggering 30-50 million people worldwide.  People died at such a high rate that cities ran out of caskets and dead bodies were stacked on porches and in the streets.

Governments have been concerned that history might repeat itself because the two flues share one thing in common–they both started out as animal viruses.  And our bodies are not particularly good at fighting off viruses new to humans.

Each year a new flock of flu strains kicks off the flu season.  Almost always these strains are variations of human flues from previous years.  What this means is that we have seen cousins of these viruses in the past and so have a leg up on mounting an attack and defeating them.

We do not have this same leg up on animal viruses.  Our immune systems haven't seen anything like them and so can't mount a quick attack.  The end result is that the percentage of people who die from animal flues tends to be much higher than from run of the mill human flues.

In any flu season, the CDC estimates that 5-20% of the U.S. population ends up with the flu.  And that 36,000 of these people die.  The numbers of deaths would be much higher if a truly deadly animal flu virus like the bird flu from a few years back were to emerge and gain the ability to spread from person to person.  (The bird flu was never more than a few isolated cases since it never gained this ability.)

At first blush, this is what the swine flu looked like.  The disease spread easily among people and, in Mexico at least, appeared to be more deadly than normal flues.  So governments around the world sprang into action.  Since flu is spread through contact, governments tried to keep people away from each other.

They closed schools at the fist sign of trouble.  Mexico closed restaurants, theaters and museums too.  All of this was done in an attempt to prevent the spread of a disease like the flu of 1918.

At least outside of Mexico, this flu does not seem to be too much worse than other flues.  So it may be that governments overreacted this time.  But I would prefer that they overreact like this as opposed to ignoring a deadly pandemic.  We don't want another 1918 on our hands.

More info on The 1918 Flu in San Francisco

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The swine flu virus. Credit: C. S. Goldsmith and A. Balish, CDC.

As this story is being produced, the reports on swine flu are changing hourly. Cases are popping up closer and closer to home, and the CDC is updating several times a day on the spread of the virus, and plans to fight it.

The $64,000 question is how worried we should be.

Swine flu is largely untreatable: The two effective antiviral drugs, Tamiflu and Relenza, must be taken within 48 hours of infection to stop the spread of the virus.

That leaves a vaccine. Vaccines are relatively straightforward to create, but they take time. If swine flu becomes a deadly pandemic (meaning it's not only widespread — a pandemic – but more lethal than it appears to be so far) the demand for vaccines would likely far outpace supply. According to Art Reingold, at UC Berkeley's School of Public Health, it could take years for doses to reach everyone in the world who's vulnerable to the disease. Here in the US, we have very few vaccine producing facilities, which means we'd be competing with other countries' priorities to treat their own citizens.

Our story focuses on what could, one day, be the answer to pandemics like this one: a universal vaccine. Scientists like Harvard Medical School's Wayne Marasco believe that, in just a few years, we might be able to inoculate ourselves against nearly all influenza viruses – like a tetanus shot, against the flu. Universal vaccines will come too late for our current swine flu pandemic. But they may well be our response to pandemics of the future.

Listen to the Swine Flu and You radio report online.

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The swine flu virus, up close (and colorized!)
Credit: C. S. Goldsmith and A. Balish, CDC

Swine Flu has been blanketing the news as of late. On April 29th, the Centers for Disease Control and Prevention (CDC) reported the first US fatality occurring in Texas. The CDC has determined that this swine influenza A(H1N1) virus is contagious and spreading from human to human. Yet at this time, they do not know how easily the virus spreads between people. At our museum, we have taken this very seriously and staff has been asked to stay home if symptoms arise.

CDC is recommending that those who come down with flu-like symptoms stay home from work in order to decrease the rate of infection. The Swine Flu is a viral infection rather than a bacterial infection, which makes it harder to treat. Much of the care for viruses is preventive; viruses are hard to treat after they have entered a living host.

Many people do not know the difference between a viral infection and a bacterial one and consider them interchangeable. Yet they are quite different. Viruses are sub-microscopic particles ranging in size from 20 to 300 nanometers (about 1000 times smaller than the width of a human hair). Viruses must have a living host to function. They remain dormant until they infect a living cell. Within a cell, they then change the genetic material of the cell to replicate the virus. AIDS and Influenza are both created by this process of taking over the normal function of a cell in order to replicate viral cells.

Bacteria do not take over cells. Bacteria are much larger than viruses, usually 10 to 100 times bigger than a virus. Their shapes include curved rods, spheres, rods and spirals. They are known as intercellular organisms because they live between cells. All viruses are harmful to the host because they alter cells, but bacteria can be beneficial (like the species that live in our guts and help us digest our food).

Harmful bacteria in the body create infections like Strep throat or Small Pox. Bacteria can grow and reproduce in both living and non-living environments. Antibiotics are used to treat harmful bacterial growth and infection in the body. Antibiotics; however, are ineffectual against treating viruses.

Because the Swine Flu is a virally spread disease, it is even more important to practice prevention. The CDC sees this disease being spread like a common flu – mainly from person to person through coughing or sneezing by people with influenza. People can also become infected by touching something with flu viruses on it and then touching their mouth or nose. Taking simple precautions like washing your hands and covering your mouth when sneezing is effective prevention. Working in a museum,we take this extra seriously considering how often we come in contact with lots of people and their germs. Many of my co-workers, myself included, have hand sanitizer at our desks, wash our hands often, and carry tissues. It is a simple way to combat an evasive illness.

For more about how to protect yourself from swine flu, check out this podcast from the CDC.

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