Stanford University.

On Wednesday, scientists at Stanford Medical School released new images they’ve produced showing a slice of a mouse’s cerebral cortex. The images, captured using a technology called array tomography, show individual neurons and synapses. Synapses – which are less than a thousandth of a millimeter in diameter – allow brain cells to communicate with each other.

The idea, said Stephen Smith, a professor of molecular and cellular physiology at Stanford Medical School, is that one day scientists might be able to map the changes in individual synapses that occur when people, say, learn a new skill, or experience pain or disease.

That’s a tall order, considering the number of synapses there are in a human brain. Smith says in the human cerebral cortex alone, there are 125 trillion synapses – as many stars as you’d find in 1,500 Milky Ways.

These images – set, in this video, to music composed by Smith’s daughter – are a step in that direction. Smith said the images “have revealed to me, in a way I wasn’t entirely prepared for, how incredibly beautiful the insides of the brain are.”

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This radio story tries to cram a lot into five minutes, so if you don't find what you need here, put a comment on the blog, below and I'll see if I can't provide a lead to more information.

Transcranial magnetic stimulation interested me, in part, because of how non-invasive it is. Dr. Bret Schneider, who offers TMS from his private practice in Portola Valley, was one of several experts to suggest that TMS machines might one day be available for home use. Of course, that's a long way off. TMS is expensive: about $5,000 for an initial round of treatment. It's still much easier and cheaper to simply pop a pill each morning. And researchers are still working out how effective it can be.

Studies show that TMS brings a remission in depression to about a third of patients to try it. Another third experience some improvement, and a final third are unaffected. Dr. Schneider says he sees much better success rates on patients who combine TMS with antidepressant drugs (TMS without drugs, he says, is like "trying to drive a car with no gas.") Finally, the FDA approval covers only one TMS machine on the market, Neurostar, although some physicians use other techniques, off-label.

You can find links to the abstracts of clinical studies performed on TMS and depression through a search at pubmed.com. This meta-analysis compares 30 double-blind studies, covering a total of 1164 patients (606 received TMS, 558 received sham treatments).

But TMS is just one in a class of "brain stimulation" depression treatments — an important fact that didn't make it into the story. Others include vagus nerve stimulation, deep brain stimulation and, of course, electroshock convulsive therapy — which is offered here in the Bay Area at the UCSF Langley Porter Psychiatric Institute to severely depressed patients (as well as, less commonly, people suffering from manic depression and schizophrenia).

Quest TV will cover TMS and other depression treatments in greater depth later this season, so stay tuned. For a sneak peak at some of what you'll find on the show, check out Stanford scientist Karl Deisseroth's groundbreaking work using light-sensitive proteins to stimulate neural circuits — work that could someday help treat not just depression, but other brain diseases as well.

Listen to the Depression Advancements radio report online or check out the slideshow below of Dr. Bret Schneider, a consulting assistant professor at Stanford University and a practicing psychiatrist in Portola Valley, discussing depression and the brain.

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Bio-inspired design borrows its creative inspiration from models and systems in nature, that is, plant and animal parts that have been slowly tweaked for over 3.8 billion years. But that doesn't mean that nature's designs are perfect. In fact, that's what makes the process of engineering things based on natural models so difficult. You have to figure out how to pull the aces from the evolutionary discard pile. As professor Bob Full at U.C. Berkeley explained in our first phone conversation, that's also why scientists now use the term "bio-inspiration" rather than the more commonly known term "biomimicry." Biologists and engineers are not looking to simply mimic nature, because there are all kinds of dead ends and redundancies in natural systems that would be pointless to recreate in an optimized, man-made piece of technology. One of the examples he gave me is a kind of grasshopper that if you were to copy it, you would copy neurons that go to nothing, they don't connect to any muscles, and that's because during evolution the adults lost their ability to fly. The neurons going to the muscles are still there, but the muscles aren't there anymore. No need to copy that, right?

So what a biomimeticist does is look to nature to find plants & animals with remarkable performance abilities, and studies their adaptations for inspiration to design something new. For example, if you want to make a tiny robot that can fly, then look at the best fliers. If you want to design a blade that moves quickly through fluids, or an Olympic swimsuit that minimizes drag, then look to the most efficient swimmers. Now that's what I call "intelligent design!"

Watch the Bio-Inspiration: Nature as Muse television story report online.

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