Patient-Specific DNA Sequencing Finally Paying Off
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Barry Starr","firstName":"Dr. Barry","lastName":"Starr","slug":"dr-barry-starr","email":"bstarr@thetech.org","display_author_email":false,"staff_mastheads":[],"title":null,"bio":"Dr. Barry Starr (\u003ca href=\"https://twitter.com/geneticsboy\">@geneticsboy\u003c/a>) is a Geneticist-in-Residence at The Tech Museum of Innovation in San Jose, CA and runs their Stanford at The Tech program. The program is part of an ongoing collaboration between the \u003ca href=\"http://genetics.stanford.edu/\">Stanford Department of Genetics\u003c/a> and \u003ca href=\"http://www.thetech.org/\">The Tech Museum of Innovation\u003c/a>. Together these two partners created the \u003ca href=\"http://www.thetech.org/exhibits/permanent/index.php?sGalKey=gtwt&galKey=lt\">Genetics: Technology with a Twist\u003c/a> exhibition.\r\n\r\nYou can also see \u003ca href=\"https://ww2.kqed.org/science/author/dr-barry-starr/\">additional posts by Barry at KQED Science\u003c/a>, and read his \u003ca href=\"http://science.kqed.org/quest/author/dr-barry-starr/\">previous contributions\u003c/a> to \u003ca href=\"http://science.kqed.org/quest/\">QUEST\u003c/a>, a project dedicated to exploring the Science of Sustainability.","avatar":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g","twitter":"geneticsboy","facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"science","roles":["author"]},{"site":"quest","roles":["subscriber"]}],"headData":{"title":"Dr. Barry Starr | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/dr-barry-starr"}},"breakingNewsReducer":{},"campaignFinanceReducer":{},"firebase":{"requesting":{},"requested":{},"timestamps":{},"data":{},"ordered":{},"auth":{"isLoaded":false,"isEmpty":true},"authError":null,"profile":{"isLoaded":false,"isEmpty":true},"listeners":{"byId":{},"allIds":[]},"isInitializing":false,"errors":[]},"navBarReducer":{"navBarId":"home","fullView":true,"showPlayer":false},"navMenuReducer":{"menus":[{"key":"menu1","items":[{"name":"News","link":"/","type":"title"},{"name":"Politics","link":"/politics"},{"name":"Science","link":"/science"},{"name":"Education","link":"/educationnews"},{"name":"Housing","link":"/housing"},{"name":"Immigration","link":"/immigration"},{"name":"Criminal Justice","link":"/criminaljustice"},{"name":"Silicon Valley","link":"/siliconvalley"},{"name":"Forum","link":"/forum"},{"name":"The California Report","link":"/californiareport"}]},{"key":"menu2","items":[{"name":"Arts & Culture","link":"/arts","type":"title"},{"name":"Critics’ Picks","link":"/thedolist"},{"name":"Cultural Commentary","link":"/artscommentary"},{"name":"Food & Drink","link":"/food"},{"name":"Bay Area Hip-Hop","link":"/bayareahiphop"},{"name":"Rebel Girls","link":"/rebelgirls"},{"name":"Arts Video","link":"/artsvideos"}]},{"key":"menu3","items":[{"name":"Podcasts","link":"/podcasts","type":"title"},{"name":"Bay Curious","link":"/podcasts/baycurious"},{"name":"Rightnowish","link":"/podcasts/rightnowish"},{"name":"The Bay","link":"/podcasts/thebay"},{"name":"On Our Watch","link":"/podcasts/onourwatch"},{"name":"Mindshift","link":"/podcasts/mindshift"},{"name":"Consider This","link":"/podcasts/considerthis"},{"name":"Political Breakdown","link":"/podcasts/politicalbreakdown"}]},{"key":"menu4","items":[{"name":"Live Radio","link":"/radio","type":"title"},{"name":"TV","link":"/tv","type":"title"},{"name":"Events","link":"/events","type":"title"},{"name":"For Educators","link":"/education","type":"title"},{"name":"Support KQED","link":"/support","type":"title"},{"name":"About","link":"/about","type":"title"},{"name":"Help Center","link":"https://kqed-helpcenter.kqed.org/s","type":"title"}]}]},"pagesReducer":{},"postsReducer":{"stream_live":{"type":"live","id":"stream_live","audioUrl":"https://streams.kqed.org/kqedradio","title":"Live Stream","excerpt":"Live Stream information currently unavailable.","link":"/radio","featImg":"","label":{"name":"KQED Live","link":"/"}},"stream_kqedNewscast":{"type":"posts","id":"stream_kqedNewscast","audioUrl":"https://www.kqed.org/.stream/anon/radio/RDnews/newscast.mp3?_=1","title":"KQED Newscast","featImg":"","label":{"name":"88.5 FM","link":"/"}},"quest_15516":{"type":"posts","id":"quest_15516","meta":{"index":"posts_1591205157","site":"quest","id":"15516","score":null,"sort":[1309793064000]},"guestAuthors":[],"slug":"patient-specific-dna-sequencing-finally-paying-off","title":"Patient-Specific DNA Sequencing Finally Paying Off","publishDate":1309793064,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/06/ColorfulChromosomes1.jpg\" alt=\"\">\u003c/a>\u003cem>Scientists are finally unraveling enough of the mystery of\u003cbr>human DNA to help individual patients.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>In the last few months, a couple of stories have come out that show the promise of the upcoming genetic revolution. In each case, doctors found a patient’s best treatment by looking at every last letter of that patient’s DNA. \u003c/p>\n\u003cp>In the first \u003ca href=\"http://www.thetech.org/genetics/news.php?id=140\">case\u003c/a>, a young boy had all the hallmarks of an immune problem but there was no conclusive diagnosis. Without knowing for sure what was wrong, doctors weren’t comfortable treating the boy with a risky bone marrow transplant.\u003c/p>\n\u003cp>Then scientists sequenced the boy’s DNA. Lo and behold there was a never-before-seen mutation in a known gene. This nailed down the diagnosis of a potentially life-threatening form of irritable bowel disease (IBD).\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>The doctors went ahead with the bone marrow transplant. The boy not only survived the treatment, but his symptoms cleared up as well. He is now essentially cured because he had his DNA sequenced.\u003c/p>\n\u003cp>The second \u003ca href=\"http://www.thetech.org/genetics/news.php?id=142\">case \u003c/a>involves a set of boy-girl twins. They suffer from a movement disorder called dopamine-responsive dystonia (\u003ca href=\"http://www.dystoniacanada.org/about-dystonia/dopa-responsive-dystonia\">DRD\u003c/a>). \u003c/p>\n\u003cp>Patients with DRD are usually treated with L-dopa. This can often clear up most symptoms but didn’t seem to help these twins as much. In particular, the twin sister still suffered severe enough symptoms to greatly diminish her quality of life. \u003c/p>\n\u003cp>Scientists sequenced the twins’ DNA and found out that they had a kind of DRD that responds best to both L-dopa and a medicine called 5-HTP. Once they both received this new treatment, their symptoms improved dramatically.\u003c/p>\n\u003cp>For example, the girl used to suffer from something called layngospasms that usually ended in vomiting. With the new treatment, this went away. An obvious improvement to her life!\u003c/p>\n\u003cp>Assuming prices keep dropping for sequencing and Congress keeps allocating money for basic research, there may come a day in the not too distant future when many more patients like these will be helped. People will have better lives because doctors can figure out what is wrong by looking at their DNA. As long as doctors have the tools they need to help patients that is.\u003c/p>\n\u003cp>Right now the information is so scattered and so specialized that most doctors can’t help without a scientist’s intervention. This greatly limits the number of patients who can be helped.\u003c/p>\n\u003cp>Getting this whole process streamlined enough so that more than just the wealthy, connected, or lucky can benefit won’t be easy. We need to generate lots more data. But we also need to collect and organize the data so doctors can take a patient’s DNA data and translate it into the right treatment without the help of a genetic scientist. \u003c/p>\n\u003cp>This last part is not exciting work but is absolutely necessary if the promise of the genomic revolution is to be fully realized. Here’s hoping someone funds something like this.\u003c/p>\n\u003cp>\u003ciframe width=\"425\" height=\"349\" src=\"http://www.youtube.com/embed/jxFO-SjA-P4\" frameborder=\"0\">\u003c/iframe>\u003c/p>\n\u003cp>\u003ci>Great story about DRD and how L-dopa can help.\u003c/i>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.3393857 -121.8949555\u003c/p>\n\n","blocks":[],"excerpt":"Here Dr. Starr talks about three patients who have dramatically improved lives because scientists sequenced their DNA and correctly interpreted the results. The dream of helping individual patients using data from the human genome project is finally being realized.","status":"publish","parent":0,"modified":1309793064,"stats":{"hasAudio":false,"hasVideo":true,"hasChartOrMap":true,"iframeSrcs":["http://www.youtube.com/embed/jxFO-SjA-P4"],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":19,"wordCount":518},"headData":{"title":"Patient-Specific DNA Sequencing Finally Paying Off | KQED","description":"Here Dr. Starr talks about three patients who have dramatically improved lives because scientists sequenced their DNA and correctly interpreted the results. The dream of helping individual patients using data from the human genome project is finally being realized.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":""},"disqusIdentifier":"15516 http://www.kqed.org/quest/blog/2011/07/04/patient-specific-dna-sequencing-finally-paying-off/","disqusUrl":"https://ww2.kqed.org/quest/2011/07/04/patient-specific-dna-sequencing-finally-paying-off/","disqusTitle":"Patient-Specific DNA Sequencing Finally Paying Off","path":"/quest/15516/patient-specific-dna-sequencing-finally-paying-off","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/06/ColorfulChromosomes1.jpg\" alt=\"\">\u003c/a>\u003cem>Scientists are finally unraveling enough of the mystery of\u003cbr>human DNA to help individual patients.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>In the last few months, a couple of stories have come out that show the promise of the upcoming genetic revolution. In each case, doctors found a patient’s best treatment by looking at every last letter of that patient’s DNA. \u003c/p>\n\u003cp>In the first \u003ca href=\"http://www.thetech.org/genetics/news.php?id=140\">case\u003c/a>, a young boy had all the hallmarks of an immune problem but there was no conclusive diagnosis. Without knowing for sure what was wrong, doctors weren’t comfortable treating the boy with a risky bone marrow transplant.\u003c/p>\n\u003cp>Then scientists sequenced the boy’s DNA. Lo and behold there was a never-before-seen mutation in a known gene. This nailed down the diagnosis of a potentially life-threatening form of irritable bowel disease (IBD).\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>The doctors went ahead with the bone marrow transplant. The boy not only survived the treatment, but his symptoms cleared up as well. He is now essentially cured because he had his DNA sequenced.\u003c/p>\n\u003cp>The second \u003ca href=\"http://www.thetech.org/genetics/news.php?id=142\">case \u003c/a>involves a set of boy-girl twins. They suffer from a movement disorder called dopamine-responsive dystonia (\u003ca href=\"http://www.dystoniacanada.org/about-dystonia/dopa-responsive-dystonia\">DRD\u003c/a>). \u003c/p>\n\u003cp>Patients with DRD are usually treated with L-dopa. This can often clear up most symptoms but didn’t seem to help these twins as much. In particular, the twin sister still suffered severe enough symptoms to greatly diminish her quality of life. \u003c/p>\n\u003cp>Scientists sequenced the twins’ DNA and found out that they had a kind of DRD that responds best to both L-dopa and a medicine called 5-HTP. Once they both received this new treatment, their symptoms improved dramatically.\u003c/p>\n\u003cp>For example, the girl used to suffer from something called layngospasms that usually ended in vomiting. With the new treatment, this went away. An obvious improvement to her life!\u003c/p>\n\u003cp>Assuming prices keep dropping for sequencing and Congress keeps allocating money for basic research, there may come a day in the not too distant future when many more patients like these will be helped. People will have better lives because doctors can figure out what is wrong by looking at their DNA. As long as doctors have the tools they need to help patients that is.\u003c/p>\n\u003cp>Right now the information is so scattered and so specialized that most doctors can’t help without a scientist’s intervention. This greatly limits the number of patients who can be helped.\u003c/p>\n\u003cp>Getting this whole process streamlined enough so that more than just the wealthy, connected, or lucky can benefit won’t be easy. We need to generate lots more data. But we also need to collect and organize the data so doctors can take a patient’s DNA data and translate it into the right treatment without the help of a genetic scientist. \u003c/p>\n\u003cp>This last part is not exciting work but is absolutely necessary if the promise of the genomic revolution is to be fully realized. Here’s hoping someone funds something like this.\u003c/p>\n\u003cp>\u003ciframe width=\"425\" height=\"349\" src=\"http://www.youtube.com/embed/jxFO-SjA-P4\" frameborder=\"0\">\u003c/iframe>\u003c/p>\n\u003cp>\u003ci>Great story about DRD and how L-dopa can help.\u003c/i>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.3393857 -121.8949555\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/15516/patient-specific-dna-sequencing-finally-paying-off","authors":["6177"],"categories":["quest_4"],"tags":["quest_848","quest_3961","quest_3962","quest_1188","quest_1197","quest_3964","quest_3971","quest_3974","quest_3980"],"featImg":"quest_15523","label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. 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On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. 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