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As a key ingredient in cigarettes, the plant contributes to gum disease, emphysema and cancer. This has led to a decline in cigarette sales and tobacco production in the United States over the past 25 years. But one research team thinks tobacco could provide a societal benefit by becoming a new source for biofuel.\u003c/p>\n\u003cp>“All the things that make tobacco bad are really good for fuels,” said \u003ca href=\"http://eetd.lbl.gov/people/bill-shelander\">Bill Shelander\u003c/a>, business development specialist at\u003ca href=\"http://www.lbl.gov/\"> Lawrence Berkeley National Laboratory\u003c/a>.\u003c/p>\n\u003cp>“When you smoke cigarettes you are smoking tar and nicotine, and the tar is bad for health,” he said. “Tobacco is unusually high in tar content and it’s the type of chemical that can be converted into fuels -- they are precursors to oil. If these plants were buried for millions of years they would be a very nice oil reserve.”\u003c/p>\n\u003cp>The lab has partnered with the \u003ca href=\"http://www.berkeley.edu/index.html\">University of California-Berkeley\u003c/a> and the \u003ca href=\"http://www.uky.edu/\">University of Kentucky\u003c/a> to engineer tobacco so that its leaves produce oil that can more easily be converted into a fuel source for everything from cars to yachts.\u003c/p>\n\u003cp>The project, called \u003ca href=\"http://ucbiotech.org/folium/\">Folium\u003c/a>, is backed by a $4.8 million grant from the \u003ca href=\"http://arpa-e.energy.gov/\">Advanced Research Projects Agency-Energy\u003c/a> or ARPA-E, a \u003ca href=\"http://energy.gov/\">U.S. Department of Energy\u003c/a> agency that funds the research and development of emerging energy technologies.\u003c/p>\n\u003cfigure id=\"attachment_70734\" class=\"wp-caption alignleft\" style=\"max-width: 341px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/03/NextMeal_Tobacco_Arwen_Curry.jpg\">\u003cimg class=\"wp-image-70734\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/03/NextMeal_Tobacco_Arwen_Curry-377x253.jpg\" alt=\"NextMeal_Tobacco_Arwen_Curry\" width=\"341\" height=\"229\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Researchers introduce genes from cyanobacteria and algae to increase the amount of oil that is produced in tobacco leaves. Photo: Arwen Curry, KQED Science\u003c/figcaption>\u003c/figure>\n\u003cp>The idea for biofuel -- using plants as a fuel source -- is nothing new, but it has gained popularity in recent years with rising gasoline prices and concern that burning fossil fuels is a main driver of climate change.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>The most common source for biofuel in the U.S. is corn, which is fermented and turned into an alcohol, called ethanol, that is added to gasoline and used to power automobiles.\u003c/p>\n\u003cp>To create biofuel from tobacco, researchers have added genes from algae and cyanobacteria that can process sunlight more efficiently than corn does and convert the sunlight into hydrocarbons via photosynthesis.\u003c/p>\n\u003cp>Hydrocarbons in the engineered tobacco are a form of bio-crude oil, an antecedent to fuel. This bio-crude can be stored in the leaves and directly removed and processed to create biofuel, which requires fewer steps than making ethanol, the researchers say.\u003c/p>\n\u003cp>Because less processing is required, at a commercial scale biofuel from tobacco could be price competitive with gasoline at three to six dollars a gallon, said Peggy Lemaux, a University of California-Berkeley biologist working on the Folium team.\u003c/p>\n\u003cp>The plant has several other distinct advantages, said Lemaux. Tobacco doesn’t compete with the national food supply. It occupies 350,000 acres of land, compared to 95.3 million for corn, and is cultivated in designated areas where it has been produced for decades.\u003c/p>\n\u003cp>It also can be harvested several times a year and it produces more biomass than traditional biofuel crops.\u003c/p>\n\u003caside class=\"pullquote alignleft\">We need alternative sources of fuel, but we also need researchers to come up with remedies to end the [tobacco] industry’s behavior that harms soils and communities -Marty Ortañez \u003c/aside>\n\u003cp>Researchers at the University of Kentucky have been planting and machine harvesting tobacco on a two-acre plot to measure the potential yield. The tobacco biofuel has not been used in vehicles yet and would need more financial backing for testing after the three-year Department of Energy grant runs out this year.\u003c/p>\n\u003cp>But critics say there are lots of problems with the idea.\u003c/p>\n\u003cp>Pesticide pollution and inhumane working conditions are prevalent in the countries where tobacco is grown, said anthropology professor \u003ca href=\"http://www.ucdenver.edu/academics/colleges/CLAS/Departments/anthropology/AboutUs/Contact/DepartmentDirectory/Pages/MartyOta%C3%B1ez.aspx\">Marty Ortañez\u003c/a> of the \u003ca href=\"http://www.ucdenver.edu/pages/ucdwelcomepage.aspx\">University of Colorado Denver\u003c/a>.\u003c/p>\n\u003cp>“Tobacco is an industry that relies on child labor,” said Ortañez. “We need alternative sources of fuel, but we also need researchers to come up with remedies to end the industry’s behavior that harms soils and communities.”\u003c/p>\n\u003cp>In May, Human Rights Watch, a nonprofit advocacy group, released \u003ca href=\"http://www.hrw.org/reports/2014/05/13/tobacco-s-hidden-children\">a report\u003c/a> about the dangerous working conditions for children as young as seven who work in U.S. tobacco fields. Many young workers were exposed to pesticides and nicotine that sometimes resulted in acute nicotine poisoning.\u003c/p>\n\u003cp>Orlando Chambers, managing director of the \u003ca href=\"http://www2.ca.uky.edu/KTRDC/\">Kentucky Tobacco Research and Development Center\u003c/a> (KTRDC), said that tobacco used for biofuel would be machine harvested, making child labor a non-issue.\u003c/p>\n\u003cp>“Conventional tobacco uses lots of labor, but genetically modified tobacco would be planted closer together and be machine harvested,” Chambers said.\u003c/p>\n\u003cp>Ortañez contends that tobacco research, whether for biofuel or cancer vaccines, ultimately helps tobacco companies’ portray the industry in a positive light.\u003c/p>\n\u003cfigure id=\"attachment_70755\" class=\"wp-caption alignleft\" style=\"max-width: 343px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/03/Tobacco-harvesting_300x225.jpg\">\u003cimg class=\" wp-image-70755\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/03/Tobacco-harvesting_300x225.jpg\" alt=\"Photo: La Casa del Habano and Habanos S.A.\" width=\"343\" height=\"257\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Tobacco for cigarettes is picked by hand but tobacco grown for biofuel would be more efficiently harvested by machines. Photo: La Casa del Habano and Habanos S.A.\u003c/figcaption>\u003c/figure>\n\u003cp>“Tobacco for biofuel is just another strategy for the tobacco industry to derail the discussion about unfair contracts and low leaf prices [for farmers],” said Ortañez. “It’s the last-ditch effort of tobacco companies to represent themselves as having any sort of benefit.”\u003c/p>\n\u003cp>When contacted, cigarette manufacturer Philip Morris declined to comment for this story.\u003c/p>\n\u003cp>According to Folium biologist Peggy Lemaux, the research is neither supported nor influenced by the tobacco industry.\u003c/p>\n\u003cp>“This project had nothing to do with big tobacco,” said Lemaux. “It was thought of by a bunch of researchers because it’s not an edible crop, it has a high biomass and it’s easy to genetically manipulate.”\u003c/p>\n\u003cp>Lemaux and other scientists participating in Folium have not received money from the tobacco companies, she said.\u003c/p>\n\u003cp>Despite the problems associated with tobacco farming, Ortañez does believe Folium has merit.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>“I am excited that the biofuel project will get people talking about labor rights and unfair wages,” said Ortañez. “There’s a lot of room for tobacco to improve.”\u003c/p>\n\n","blocks":[],"excerpt":"Is a new biofuel a win for renewable energy or the far-reaching arms of the tobacco industry?","status":"publish","parent":0,"modified":1442678272,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":29,"wordCount":1020},"headData":{"title":"Tobacco Gets a Makeover as New Source for Biofuel | KQED","description":"Is a new biofuel a win for renewable energy or the far-reaching arms of the tobacco industry?","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Tobacco Gets a Makeover as New Source for Biofuel","datePublished":"2014-06-03T14:00:26.000Z","dateModified":"2015-09-19T15:57:52.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"68329 http://science.kqed.org/quest/?p=68329","disqusUrl":"https://ww2.kqed.org/quest/2014/06/03/tobacco-gets-a-makeover-as-new-source-for-biofuel/","disqusTitle":"Tobacco Gets a Makeover as New Source for Biofuel","source":"Energy","sourceUrl":"http://ww2.kqed.org/quest/category/energy/","path":"/quest/68329/tobacco-gets-a-makeover-as-new-source-for-biofuel","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>Tobacco is about to get a facelift. As a key ingredient in cigarettes, the plant contributes to gum disease, emphysema and cancer. This has led to a decline in cigarette sales and tobacco production in the United States over the past 25 years. But one research team thinks tobacco could provide a societal benefit by becoming a new source for biofuel.\u003c/p>\n\u003cp>“All the things that make tobacco bad are really good for fuels,” said \u003ca href=\"http://eetd.lbl.gov/people/bill-shelander\">Bill Shelander\u003c/a>, business development specialist at\u003ca href=\"http://www.lbl.gov/\"> Lawrence Berkeley National Laboratory\u003c/a>.\u003c/p>\n\u003cp>“When you smoke cigarettes you are smoking tar and nicotine, and the tar is bad for health,” he said. “Tobacco is unusually high in tar content and it’s the type of chemical that can be converted into fuels -- they are precursors to oil. If these plants were buried for millions of years they would be a very nice oil reserve.”\u003c/p>\n\u003cp>The lab has partnered with the \u003ca href=\"http://www.berkeley.edu/index.html\">University of California-Berkeley\u003c/a> and the \u003ca href=\"http://www.uky.edu/\">University of Kentucky\u003c/a> to engineer tobacco so that its leaves produce oil that can more easily be converted into a fuel source for everything from cars to yachts.\u003c/p>\n\u003cp>The project, called \u003ca href=\"http://ucbiotech.org/folium/\">Folium\u003c/a>, is backed by a $4.8 million grant from the \u003ca href=\"http://arpa-e.energy.gov/\">Advanced Research Projects Agency-Energy\u003c/a> or ARPA-E, a \u003ca href=\"http://energy.gov/\">U.S. Department of Energy\u003c/a> agency that funds the research and development of emerging energy technologies.\u003c/p>\n\u003cfigure id=\"attachment_70734\" class=\"wp-caption alignleft\" style=\"max-width: 341px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/03/NextMeal_Tobacco_Arwen_Curry.jpg\">\u003cimg class=\"wp-image-70734\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/03/NextMeal_Tobacco_Arwen_Curry-377x253.jpg\" alt=\"NextMeal_Tobacco_Arwen_Curry\" width=\"341\" height=\"229\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Researchers introduce genes from cyanobacteria and algae to increase the amount of oil that is produced in tobacco leaves. Photo: Arwen Curry, KQED Science\u003c/figcaption>\u003c/figure>\n\u003cp>The idea for biofuel -- using plants as a fuel source -- is nothing new, but it has gained popularity in recent years with rising gasoline prices and concern that burning fossil fuels is a main driver of climate change.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>The most common source for biofuel in the U.S. is corn, which is fermented and turned into an alcohol, called ethanol, that is added to gasoline and used to power automobiles.\u003c/p>\n\u003cp>To create biofuel from tobacco, researchers have added genes from algae and cyanobacteria that can process sunlight more efficiently than corn does and convert the sunlight into hydrocarbons via photosynthesis.\u003c/p>\n\u003cp>Hydrocarbons in the engineered tobacco are a form of bio-crude oil, an antecedent to fuel. This bio-crude can be stored in the leaves and directly removed and processed to create biofuel, which requires fewer steps than making ethanol, the researchers say.\u003c/p>\n\u003cp>Because less processing is required, at a commercial scale biofuel from tobacco could be price competitive with gasoline at three to six dollars a gallon, said Peggy Lemaux, a University of California-Berkeley biologist working on the Folium team.\u003c/p>\n\u003cp>The plant has several other distinct advantages, said Lemaux. Tobacco doesn’t compete with the national food supply. It occupies 350,000 acres of land, compared to 95.3 million for corn, and is cultivated in designated areas where it has been produced for decades.\u003c/p>\n\u003cp>It also can be harvested several times a year and it produces more biomass than traditional biofuel crops.\u003c/p>\n\u003caside class=\"pullquote alignleft\">We need alternative sources of fuel, but we also need researchers to come up with remedies to end the [tobacco] industry’s behavior that harms soils and communities -Marty Ortañez \u003c/aside>\n\u003cp>Researchers at the University of Kentucky have been planting and machine harvesting tobacco on a two-acre plot to measure the potential yield. The tobacco biofuel has not been used in vehicles yet and would need more financial backing for testing after the three-year Department of Energy grant runs out this year.\u003c/p>\n\u003cp>But critics say there are lots of problems with the idea.\u003c/p>\n\u003cp>Pesticide pollution and inhumane working conditions are prevalent in the countries where tobacco is grown, said anthropology professor \u003ca href=\"http://www.ucdenver.edu/academics/colleges/CLAS/Departments/anthropology/AboutUs/Contact/DepartmentDirectory/Pages/MartyOta%C3%B1ez.aspx\">Marty Ortañez\u003c/a> of the \u003ca href=\"http://www.ucdenver.edu/pages/ucdwelcomepage.aspx\">University of Colorado Denver\u003c/a>.\u003c/p>\n\u003cp>“Tobacco is an industry that relies on child labor,” said Ortañez. “We need alternative sources of fuel, but we also need researchers to come up with remedies to end the industry’s behavior that harms soils and communities.”\u003c/p>\n\u003cp>In May, Human Rights Watch, a nonprofit advocacy group, released \u003ca href=\"http://www.hrw.org/reports/2014/05/13/tobacco-s-hidden-children\">a report\u003c/a> about the dangerous working conditions for children as young as seven who work in U.S. tobacco fields. Many young workers were exposed to pesticides and nicotine that sometimes resulted in acute nicotine poisoning.\u003c/p>\n\u003cp>Orlando Chambers, managing director of the \u003ca href=\"http://www2.ca.uky.edu/KTRDC/\">Kentucky Tobacco Research and Development Center\u003c/a> (KTRDC), said that tobacco used for biofuel would be machine harvested, making child labor a non-issue.\u003c/p>\n\u003cp>“Conventional tobacco uses lots of labor, but genetically modified tobacco would be planted closer together and be machine harvested,” Chambers said.\u003c/p>\n\u003cp>Ortañez contends that tobacco research, whether for biofuel or cancer vaccines, ultimately helps tobacco companies’ portray the industry in a positive light.\u003c/p>\n\u003cfigure id=\"attachment_70755\" class=\"wp-caption alignleft\" style=\"max-width: 343px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/03/Tobacco-harvesting_300x225.jpg\">\u003cimg class=\" wp-image-70755\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/03/Tobacco-harvesting_300x225.jpg\" alt=\"Photo: La Casa del Habano and Habanos S.A.\" width=\"343\" height=\"257\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Tobacco for cigarettes is picked by hand but tobacco grown for biofuel would be more efficiently harvested by machines. Photo: La Casa del Habano and Habanos S.A.\u003c/figcaption>\u003c/figure>\n\u003cp>“Tobacco for biofuel is just another strategy for the tobacco industry to derail the discussion about unfair contracts and low leaf prices [for farmers],” said Ortañez. “It’s the last-ditch effort of tobacco companies to represent themselves as having any sort of benefit.”\u003c/p>\n\u003cp>When contacted, cigarette manufacturer Philip Morris declined to comment for this story.\u003c/p>\n\u003cp>According to Folium biologist Peggy Lemaux, the research is neither supported nor influenced by the tobacco industry.\u003c/p>\n\u003cp>“This project had nothing to do with big tobacco,” said Lemaux. “It was thought of by a bunch of researchers because it’s not an edible crop, it has a high biomass and it’s easy to genetically manipulate.”\u003c/p>\n\u003cp>Lemaux and other scientists participating in Folium have not received money from the tobacco companies, she said.\u003c/p>\n\u003cp>Despite the problems associated with tobacco farming, Ortañez does believe Folium has merit.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>“I am excited that the biofuel project will get people talking about labor rights and unfair wages,” said Ortañez. “There’s a lot of room for tobacco to improve.”\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/68329/tobacco-gets-a-makeover-as-new-source-for-biofuel","authors":["5432"],"categories":["quest_11765","quest_8","quest_9"],"tags":["quest_85","quest_116","quest_328","quest_12871","quest_12700","quest_12502","quest_12269","quest_9950","quest_1626","quest_12870","quest_13","quest_2409","quest_12868","quest_12869","quest_10239","quest_10240"],"featImg":"quest_70612","label":"source_quest_68329"},"quest_50649":{"type":"posts","id":"quest_50649","meta":{"index":"posts_1591205157","site":"quest","id":"50649","score":null,"sort":[1363014003000]},"guestAuthors":[],"slug":"engineering-a-virus-free-future","title":"Engineering a Virus-Free Future","publishDate":1363014003,"format":"aside","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cfigure id=\"attachment_50657\" class=\"wp-caption aligncenter\" style=\"max-width: 630px\">\u003ca href=\"http://ww2.kqed.org/quest/2013/03/11/engineering-a-virus-free-future/hivdocking/\" rel=\"attachment wp-att-50657\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/03/HIVdocking.jpg\" alt=\"One day we may all be engineered so that we are immune to all viruses (including the HIV shown here). Image courtesy of Wikimedia Commons.\" width=\"630\" height=\"361\" class=\"size-full wp-image-50657\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2013/03/HIVdocking.jpg 630w, https://ww2.kqed.org/app/uploads/sites/39/2013/03/HIVdocking-400x229.jpg 400w\" sizes=\"(max-width: 630px) 100vw, 630px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">One day we may all be engineered so that we are immune to all viruses (including the HIV shown here). Image courtesy of Wikimedia Commons.\u003c/figcaption>\u003c/figure>\n\u003cp>I have been reading a book called \u003ca href=\"http://www.amazon.com/Regenesis-Synthetic-Biology-Reinvent-Ourselves/dp/0465021751/ref=tmm_hrd_title_popover?ie=UTF8&qid=1362680681&sr=8-1\">Regenesis \u003c/a>where in one part the authors propose a way to re-engineer the human race so all people are resistant to all viruses, known and unknown. This will theoretically be possible in the next few decades (or even sooner) and, if done right, is predicted to make us resistant for a very long time and possibly even forever.\u003c/p>\n\u003cp>But as you might guess, something this radical does not come without risks. There are many possible health risks involved in a major reshaping of human DNA that essentially divorces us from the nature around us. And there are many ethical dilemmas in its implementation as well.\u003c/p>\n\u003cp>The benefits of a virus-free world are obvious. But it is an open question whether the risks outweigh these benefits.\u003c/p>\n\u003cp>\u003cstrong>Science of Complete Viral Resistance\u003c/strong>\u003c/p>\n\u003cp>The science behind all of this is plausible although it will definitely be a daunting technological challenge. The basic idea it is to change our operating system—we will be Macs in a PC world and so be immune to those pesky PC viruses.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Nature’s operating system is the genetic code. At its simplest the code is made up of 64, three letter words called codons. This is the language our genes are written in.\u003c/p>\n\u003cp>Viruses are able to infect our cells and make us sick because they use the same operating system. Basically a virus enters a cell and gives it a series of commands via the genetic code to make new viruses.\u003c/p>\n\u003cp>If we engineer our cells to speak a different language, then the viral instructions will be meaningless. Our cell will ignore the virus and eventually clear it out of our system.\u003c/p>\n\u003cp>Re-engineering a code that has been around for a billion years might sound hard, but one of its properties makes it doable. Many of those 64 words mean pretty much the same thing. Our genetic code has a lot of synonyms.\u003c/p>\n\u003cfigure id=\"attachment_50664\" class=\"wp-caption alignright\" style=\"max-width: 250px\">\u003ca href=\"http://ww2.kqed.org/quest/2013/03/11/engineering-a-virus-free-future/geneticcodesm/\" rel=\"attachment wp-att-50664\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/03/geneticCodeSM.gif\" alt=\"A simple code with lots of synonyms makes re-engineering our operating system relatively simple.\" width=\"250\" height=\"220\" class=\"size-full wp-image-50664\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">A simple code with lots of synonyms makes re-engineering our operating system relatively simple.\u003c/figcaption>\u003c/figure>\n\u003cp>The idea would be to change the meaning of a few of the synonyms. What we’d do is pick a codon, maybe TAG, and change all of the TAGs in our genes to its synonyms, TGA and TAA. Then we’d make TAG code for something else.\u003c/p>\n\u003cp>Now when a virus enters the cell, its instructions to the cell are gibberish. Whenever it gives cells an instruction with TAG somewhere in it, the cell misreads it and so can’t do as it is told. The cell can then calmly ignore the virus and go about its business. (Click \u003ca href=\"http://genetics.thetech.org/ask-a-geneticist/viral-resistance\">here \u003c/a>to learn more about the science behind this.)\u003c/p>\n\u003cp>Making the resistance more or less permanent requires changing more than one synonym. Viruses are small and mutate like crazy so we have to make it so the virus requires at least ten and probably many more simultaneous mutations to become resistant. The only way to do this is if we make all the changes in one fell swoop.\u003c/p>\n\u003cp>This all sounds like some Hollywood \"B movie\" but \u003ca href=\"http://ww2.kqed.org/quest/2011/08/15/redesigning-life/\">scientists are very close\u003c/a> to testing this theory out in \u003cem>E. coli\u003c/em>, a common lab bacterium. Scientists have made the appropriate changes and are stitching together the DNA as we speak. Soon we should know if this strain of \u003cem>E. coli\u003c/em> is immune to the phages that plague it. (Phages are what viruses that attack bacteria are called.)\u003c/p>\n\u003cp>If this works in bacteria, then it might work in people too. But it isn’t a for sure thing. We are more complicated than a bacterium and the genetic code is more complicated than it first appears.\u003c/p>\n\u003cp>A big challenge that has important implications is that we can’t make the necessary changes a bit at a time. If we do that, viruses will mutate along with us and keep up. We need to make all the tens of thousands of changes all at once. This is where the trouble can start.\u003c/p>\n\u003cp>\u003cstrong>Technical Risks\u003c/strong>\u003c/p>\n\u003cp>There are at least two sets of technical risks associated with doing something like this. The first just has to do with how often we make a mistake while changing tens of thousands of our DNA letters. No matter how good we get, there will always be a chance that we make a mistake. And since these changes are in genes, some of the mistakes could be really bad for our health. I am not sure we can ever be careful enough to not introduce a few errors here and there.\u003c/p>\n\u003cp>The second big risk is that we do not fully understand how our DNA works. What if there are very small genes we don’t know about that use the synonym that we have changed? The consequences could be severe if that “genelet” plays an important role in the cell.\u003c/p>\n\u003cp>Another problem in that the synonyms may not be as alike as we think. We’ve known for a while that not all synonymous codons are created equal. For example, sometimes when we try to optimize a gene by selecting what we think are better codons, the gene stops working. \u003c/p>\n\u003cfigure id=\"attachment_50677\" class=\"wp-caption alignleft\" style=\"max-width: 250px\">\u003ca href=\"http://ww2.kqed.org/quest/2013/03/11/engineering-a-virus-free-future/geneticengineering/\" rel=\"attachment wp-att-50677\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/03/GeneticEngineering.jpg\" alt=\"We are bound to make a few mistakes when making so many changes to our DNA.\" width=\"250\" height=\"250\" class=\"size-full wp-image-50677\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2013/03/GeneticEngineering.jpg 250w, https://ww2.kqed.org/app/uploads/sites/39/2013/03/GeneticEngineering-32x32.jpg 32w, https://ww2.kqed.org/app/uploads/sites/39/2013/03/GeneticEngineering-64x64.jpg 64w, https://ww2.kqed.org/app/uploads/sites/39/2013/03/GeneticEngineering-96x96.jpg 96w, https://ww2.kqed.org/app/uploads/sites/39/2013/03/GeneticEngineering-128x128.jpg 128w, https://ww2.kqed.org/app/uploads/sites/39/2013/03/GeneticEngineering-75x75.jpg 75w\" sizes=\"(max-width: 250px) 100vw, 250px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">We are bound to make a few mistakes when making so many changes to our DNA.\u003c/figcaption>\u003c/figure>\n\u003cp>A \u003ca href=\"http://www.yeastgenome.org/the-rhythm-of-ribosomes\">study \u003c/a>just out in yeast confirms that some of the specific codons in a gene are there for a reason—not all synonymous codons are used in the same way in the cell. It looks like some words are preferred at certain parts of a gene. \u003c/p>\n\u003cp>This means we may not be able to simply swap one codon out for another in a gene. And since all the genes are competing for a limited amount of machinery using specific codons, we don’t really know what effect eliminating all these codons will have on all 20,000 or 25,000 of our genes. We may slow things down as the parts of the cell all compete for these limited resources.\u003c/p>\n\u003cp>What makes each of these problems worse is that we will need to make all the changes at once in a cell to keep viruses from catching up to us. We will be able to test a lot beforehand, but it may not be enough. We may miss something and that would be unacceptable here.\u003c/p>\n\u003cp>Remember, we are talking about people here not bacteria, yeast or daisies. Mistakes mean a dead baby or one with disabilities. I am not sure there will ever be enough testing to make this safe enough to be worthwhile.\u003c/p>\n\u003cp>\u003cstrong>Implementation Risks\u003c/strong>\u003c/p>\n\u003cp>As you’ve seen, there are definitely health risks associated with doing this (I’m sure I haven’t thought of them all). But the ethical risks might be worse.\u003c/p>\n\u003cp>These changes can’t be made in any of us alive today. They would have to be made by inserting the changed DNA into a stem cell and coaxing that stem cell into becoming an embryo. This means that instead of changing the current human race, we’d be creating a new one.\u003c/p>\n\u003cp>An immediate problem is how we choose who gets to be virus-resistant. And scarily still, whose DNA gets to live on. So the first step will be figuring out who gets to have virus-free children and how we “choose” what DNA that child will have.\u003c/p>\n\u003cp>One way would be to make it so everyone who wants a child gets the option of having the child be virus-resistant. Maybe parents fertilize an egg the old fashioned way, the embryo’s DNA is sequenced and the DNA made matches this embryo’s. This makes me a little squeamish and is a strange gray area. We have eliminated the embryo but essentially cloned it…is the child truly identical?\u003c/p>\n\u003cfigure id=\"attachment_50683\" class=\"wp-caption alignright\" style=\"max-width: 150px\">\u003ca href=\"http://ww2.kqed.org/quest/2013/03/11/engineering-a-virus-free-future/atcgpeople-2/\" rel=\"attachment wp-att-50683\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/03/atcgPeople.jpg\" alt=\"This sort of re-engineering might result in two species of humans that cannot interbreed. Yikes.\" width=\"150\" height=\"184\" class=\"size-full wp-image-50683\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">This sort of re-engineering might result in two species of humans that cannot interbreed. Yikes.\u003c/figcaption>\u003c/figure>\n\u003cp>Another option would be to use a computer to generate a mix of the parents’ DNA and then to make that DNA and grow it into a child. This is scary as you know people will be tempted to choose the DNA rather than letting it come down to chance. We’ll definitely end up with a very different human race in the end.\u003c/p>\n\u003cp>Both of these would be pretty expensive dollar-wise but are better than an option where a chosen few get to have virus-free kids. How would that decision be made and who gets to make it? (Hint: The poor would be poorly represented.)\u003c/p>\n\u003cp>Whatever option we choose, there will still be another key issue. Engineered humans and natural humans won’t be able to have kids together. This opens up a whole can of worms if the two groups are around together for any length of time. And chances are they will (unless we outlaw having kids the old fashioned way). We will have artificially speciated the human race!\u003c/p>\n\u003cp>There is no way that comes out well. Most likely we’ll split into a group of haves and have nots decided by genetics. The engineered humans will have kids together and the natural humans will too. Occasionally a natural human could make enough money to have an engineered child but for the most part they’d be separated. I’ll let you paint that dystopic future in your head!\u003c/p>\n\u003cp>These are a few of the ethical dilemmas I can think of off the top of my head. I am sure there are many more.\u003c/p>\n\u003cp>This may all seem like a problem for Captain Kirk, but it is closer than you might think. It is really important to start talking about this stuff now so we can think out how we are going to deal with these sorts of decisions in coming decades. Before we know it, the need to decide will be upon us.\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>\u003cem>(And I didn’t even bring up the scary possibility of some Bond villain creating a virus-resistant army and then unleashing a deadly virus on the rest of us. Hey, maybe I need to send this idea to Hollywood!)\u003c/em>\u003c/p>\n\n","blocks":[],"excerpt":"I have been reading a book called \"Regenesis\" where in one part the authors propose a way to re-engineer the human race so all people are resistant to all viruses, known and unknown. This will theoretically be possible in the next few decades (or even sooner) and, if done right, is predicted to make us resistant for a very long time and possibly even forever.","status":"publish","parent":0,"modified":1363979854,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":37,"wordCount":1742},"headData":{"title":"Engineering a Virus-Free Future | KQED","description":"I have been reading a book called "Regenesis" where in one part the authors propose a way to re-engineer the human race so all people are resistant to all viruses, known and unknown. This will theoretically be possible in the next few decades (or even sooner) and, if done right, is predicted to make us resistant for a very long time and possibly even forever.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Engineering a Virus-Free Future","datePublished":"2013-03-11T15:00:03.000Z","dateModified":"2013-03-22T19:17:34.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"50649 http://science.kqed.org/quest/?p=50649","disqusUrl":"https://ww2.kqed.org/quest/2013/03/11/engineering-a-virus-free-future/","disqusTitle":"Engineering a Virus-Free Future","path":"/quest/50649/engineering-a-virus-free-future","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_50657\" class=\"wp-caption aligncenter\" style=\"max-width: 630px\">\u003ca href=\"http://ww2.kqed.org/quest/2013/03/11/engineering-a-virus-free-future/hivdocking/\" rel=\"attachment wp-att-50657\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/03/HIVdocking.jpg\" alt=\"One day we may all be engineered so that we are immune to all viruses (including the HIV shown here). Image courtesy of Wikimedia Commons.\" width=\"630\" height=\"361\" class=\"size-full wp-image-50657\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2013/03/HIVdocking.jpg 630w, https://ww2.kqed.org/app/uploads/sites/39/2013/03/HIVdocking-400x229.jpg 400w\" sizes=\"(max-width: 630px) 100vw, 630px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">One day we may all be engineered so that we are immune to all viruses (including the HIV shown here). Image courtesy of Wikimedia Commons.\u003c/figcaption>\u003c/figure>\n\u003cp>I have been reading a book called \u003ca href=\"http://www.amazon.com/Regenesis-Synthetic-Biology-Reinvent-Ourselves/dp/0465021751/ref=tmm_hrd_title_popover?ie=UTF8&qid=1362680681&sr=8-1\">Regenesis \u003c/a>where in one part the authors propose a way to re-engineer the human race so all people are resistant to all viruses, known and unknown. This will theoretically be possible in the next few decades (or even sooner) and, if done right, is predicted to make us resistant for a very long time and possibly even forever.\u003c/p>\n\u003cp>But as you might guess, something this radical does not come without risks. There are many possible health risks involved in a major reshaping of human DNA that essentially divorces us from the nature around us. And there are many ethical dilemmas in its implementation as well.\u003c/p>\n\u003cp>The benefits of a virus-free world are obvious. But it is an open question whether the risks outweigh these benefits.\u003c/p>\n\u003cp>\u003cstrong>Science of Complete Viral Resistance\u003c/strong>\u003c/p>\n\u003cp>The science behind all of this is plausible although it will definitely be a daunting technological challenge. The basic idea it is to change our operating system—we will be Macs in a PC world and so be immune to those pesky PC viruses.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Nature’s operating system is the genetic code. At its simplest the code is made up of 64, three letter words called codons. This is the language our genes are written in.\u003c/p>\n\u003cp>Viruses are able to infect our cells and make us sick because they use the same operating system. Basically a virus enters a cell and gives it a series of commands via the genetic code to make new viruses.\u003c/p>\n\u003cp>If we engineer our cells to speak a different language, then the viral instructions will be meaningless. Our cell will ignore the virus and eventually clear it out of our system.\u003c/p>\n\u003cp>Re-engineering a code that has been around for a billion years might sound hard, but one of its properties makes it doable. Many of those 64 words mean pretty much the same thing. Our genetic code has a lot of synonyms.\u003c/p>\n\u003cfigure id=\"attachment_50664\" class=\"wp-caption alignright\" style=\"max-width: 250px\">\u003ca href=\"http://ww2.kqed.org/quest/2013/03/11/engineering-a-virus-free-future/geneticcodesm/\" rel=\"attachment wp-att-50664\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/03/geneticCodeSM.gif\" alt=\"A simple code with lots of synonyms makes re-engineering our operating system relatively simple.\" width=\"250\" height=\"220\" class=\"size-full wp-image-50664\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">A simple code with lots of synonyms makes re-engineering our operating system relatively simple.\u003c/figcaption>\u003c/figure>\n\u003cp>The idea would be to change the meaning of a few of the synonyms. What we’d do is pick a codon, maybe TAG, and change all of the TAGs in our genes to its synonyms, TGA and TAA. Then we’d make TAG code for something else.\u003c/p>\n\u003cp>Now when a virus enters the cell, its instructions to the cell are gibberish. Whenever it gives cells an instruction with TAG somewhere in it, the cell misreads it and so can’t do as it is told. The cell can then calmly ignore the virus and go about its business. (Click \u003ca href=\"http://genetics.thetech.org/ask-a-geneticist/viral-resistance\">here \u003c/a>to learn more about the science behind this.)\u003c/p>\n\u003cp>Making the resistance more or less permanent requires changing more than one synonym. Viruses are small and mutate like crazy so we have to make it so the virus requires at least ten and probably many more simultaneous mutations to become resistant. The only way to do this is if we make all the changes in one fell swoop.\u003c/p>\n\u003cp>This all sounds like some Hollywood \"B movie\" but \u003ca href=\"http://ww2.kqed.org/quest/2011/08/15/redesigning-life/\">scientists are very close\u003c/a> to testing this theory out in \u003cem>E. coli\u003c/em>, a common lab bacterium. Scientists have made the appropriate changes and are stitching together the DNA as we speak. Soon we should know if this strain of \u003cem>E. coli\u003c/em> is immune to the phages that plague it. (Phages are what viruses that attack bacteria are called.)\u003c/p>\n\u003cp>If this works in bacteria, then it might work in people too. But it isn’t a for sure thing. We are more complicated than a bacterium and the genetic code is more complicated than it first appears.\u003c/p>\n\u003cp>A big challenge that has important implications is that we can’t make the necessary changes a bit at a time. If we do that, viruses will mutate along with us and keep up. We need to make all the tens of thousands of changes all at once. This is where the trouble can start.\u003c/p>\n\u003cp>\u003cstrong>Technical Risks\u003c/strong>\u003c/p>\n\u003cp>There are at least two sets of technical risks associated with doing something like this. The first just has to do with how often we make a mistake while changing tens of thousands of our DNA letters. No matter how good we get, there will always be a chance that we make a mistake. And since these changes are in genes, some of the mistakes could be really bad for our health. I am not sure we can ever be careful enough to not introduce a few errors here and there.\u003c/p>\n\u003cp>The second big risk is that we do not fully understand how our DNA works. What if there are very small genes we don’t know about that use the synonym that we have changed? The consequences could be severe if that “genelet” plays an important role in the cell.\u003c/p>\n\u003cp>Another problem in that the synonyms may not be as alike as we think. We’ve known for a while that not all synonymous codons are created equal. For example, sometimes when we try to optimize a gene by selecting what we think are better codons, the gene stops working. \u003c/p>\n\u003cfigure id=\"attachment_50677\" class=\"wp-caption alignleft\" style=\"max-width: 250px\">\u003ca href=\"http://ww2.kqed.org/quest/2013/03/11/engineering-a-virus-free-future/geneticengineering/\" rel=\"attachment wp-att-50677\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/03/GeneticEngineering.jpg\" alt=\"We are bound to make a few mistakes when making so many changes to our DNA.\" width=\"250\" height=\"250\" class=\"size-full wp-image-50677\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2013/03/GeneticEngineering.jpg 250w, https://ww2.kqed.org/app/uploads/sites/39/2013/03/GeneticEngineering-32x32.jpg 32w, https://ww2.kqed.org/app/uploads/sites/39/2013/03/GeneticEngineering-64x64.jpg 64w, https://ww2.kqed.org/app/uploads/sites/39/2013/03/GeneticEngineering-96x96.jpg 96w, https://ww2.kqed.org/app/uploads/sites/39/2013/03/GeneticEngineering-128x128.jpg 128w, https://ww2.kqed.org/app/uploads/sites/39/2013/03/GeneticEngineering-75x75.jpg 75w\" sizes=\"(max-width: 250px) 100vw, 250px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">We are bound to make a few mistakes when making so many changes to our DNA.\u003c/figcaption>\u003c/figure>\n\u003cp>A \u003ca href=\"http://www.yeastgenome.org/the-rhythm-of-ribosomes\">study \u003c/a>just out in yeast confirms that some of the specific codons in a gene are there for a reason—not all synonymous codons are used in the same way in the cell. It looks like some words are preferred at certain parts of a gene. \u003c/p>\n\u003cp>This means we may not be able to simply swap one codon out for another in a gene. And since all the genes are competing for a limited amount of machinery using specific codons, we don’t really know what effect eliminating all these codons will have on all 20,000 or 25,000 of our genes. We may slow things down as the parts of the cell all compete for these limited resources.\u003c/p>\n\u003cp>What makes each of these problems worse is that we will need to make all the changes at once in a cell to keep viruses from catching up to us. We will be able to test a lot beforehand, but it may not be enough. We may miss something and that would be unacceptable here.\u003c/p>\n\u003cp>Remember, we are talking about people here not bacteria, yeast or daisies. Mistakes mean a dead baby or one with disabilities. I am not sure there will ever be enough testing to make this safe enough to be worthwhile.\u003c/p>\n\u003cp>\u003cstrong>Implementation Risks\u003c/strong>\u003c/p>\n\u003cp>As you’ve seen, there are definitely health risks associated with doing this (I’m sure I haven’t thought of them all). But the ethical risks might be worse.\u003c/p>\n\u003cp>These changes can’t be made in any of us alive today. They would have to be made by inserting the changed DNA into a stem cell and coaxing that stem cell into becoming an embryo. This means that instead of changing the current human race, we’d be creating a new one.\u003c/p>\n\u003cp>An immediate problem is how we choose who gets to be virus-resistant. And scarily still, whose DNA gets to live on. So the first step will be figuring out who gets to have virus-free children and how we “choose” what DNA that child will have.\u003c/p>\n\u003cp>One way would be to make it so everyone who wants a child gets the option of having the child be virus-resistant. Maybe parents fertilize an egg the old fashioned way, the embryo’s DNA is sequenced and the DNA made matches this embryo’s. This makes me a little squeamish and is a strange gray area. We have eliminated the embryo but essentially cloned it…is the child truly identical?\u003c/p>\n\u003cfigure id=\"attachment_50683\" class=\"wp-caption alignright\" style=\"max-width: 150px\">\u003ca href=\"http://ww2.kqed.org/quest/2013/03/11/engineering-a-virus-free-future/atcgpeople-2/\" rel=\"attachment wp-att-50683\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2013/03/atcgPeople.jpg\" alt=\"This sort of re-engineering might result in two species of humans that cannot interbreed. Yikes.\" width=\"150\" height=\"184\" class=\"size-full wp-image-50683\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">This sort of re-engineering might result in two species of humans that cannot interbreed. Yikes.\u003c/figcaption>\u003c/figure>\n\u003cp>Another option would be to use a computer to generate a mix of the parents’ DNA and then to make that DNA and grow it into a child. This is scary as you know people will be tempted to choose the DNA rather than letting it come down to chance. We’ll definitely end up with a very different human race in the end.\u003c/p>\n\u003cp>Both of these would be pretty expensive dollar-wise but are better than an option where a chosen few get to have virus-free kids. How would that decision be made and who gets to make it? (Hint: The poor would be poorly represented.)\u003c/p>\n\u003cp>Whatever option we choose, there will still be another key issue. Engineered humans and natural humans won’t be able to have kids together. This opens up a whole can of worms if the two groups are around together for any length of time. And chances are they will (unless we outlaw having kids the old fashioned way). We will have artificially speciated the human race!\u003c/p>\n\u003cp>There is no way that comes out well. Most likely we’ll split into a group of haves and have nots decided by genetics. The engineered humans will have kids together and the natural humans will too. Occasionally a natural human could make enough money to have an engineered child but for the most part they’d be separated. I’ll let you paint that dystopic future in your head!\u003c/p>\n\u003cp>These are a few of the ethical dilemmas I can think of off the top of my head. I am sure there are many more.\u003c/p>\n\u003cp>This may all seem like a problem for Captain Kirk, but it is closer than you might think. It is really important to start talking about this stuff now so we can think out how we are going to deal with these sorts of decisions in coming decades. Before we know it, the need to decide will be upon us.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003cem>(And I didn’t even bring up the scary possibility of some Bond villain creating a virus-resistant army and then unleashing a deadly virus on the rest of us. Hey, maybe I need to send this idea to Hollywood!)\u003c/em>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/50649/engineering-a-virus-free-future","authors":["6177"],"categories":["quest_4"],"tags":["quest_9950","quest_13202","quest_11827","quest_2861","quest_3319","quest_3082"],"featImg":"quest_50657","label":"quest"},"quest_22140":{"type":"posts","id":"quest_22140","meta":{"index":"posts_1591205157","site":"quest","id":"22140","score":null,"sort":[1313429863000]},"guestAuthors":[],"slug":"redesigning-life","title":"Redesigning Life","publishDate":1313429863,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cfigure id=\"attachment_22143\" class=\"wp-caption aligncenter\" style=\"max-width: 639px\">\u003ca href=\"http://ww2.kqed.org/quest/2011/08/15/redesigning-life/coloredbacteria/\" rel=\"attachment wp-att-22143\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/08/ColoredBacteria.jpg\" alt=\"\" title=\"ColoredBacteria\" width=\"639\" height=\"359\" class=\"size-full wp-image-22143\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2011/08/ColoredBacteria.jpg 639w, https://ww2.kqed.org/app/uploads/sites/39/2011/08/ColoredBacteria-400x225.jpg 400w\" sizes=\"(max-width: 639px) 100vw, 639px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Scientists are redesigning bacteria like these to “speak” a new language. \u003c/figcaption>\u003c/figure>\n\u003cp>All living things pretty much use the same language to read their genes. That is about to change. \u003c/p>\n\u003cp>\u003ca href=\"http://www.thetech.org/genetics/news.php?id=144\">Scientists in Boston\u003c/a> are close to teaching a strain of bacteria a new dialect of the genetic code. In combination with some work done by a different \u003ca href=\"http://www.thetech.org/genetics/news.php?id=129\">group in 2010\u003c/a>, we are now getting to the point where we can actually think about (re)designing life. Which is a big step from what we have been able to do up until now.\u003c/p>\n\u003cp>The genetic engineering we have done in the past has been pretty crude. We have mostly added pre-existing genes to cells to give the cells new properties or to have the cells make something for us. \u003c/p>\n\u003cp>So we add a human gene to bacteria so they will make insulin for us. Or we add a gene from bacteria to a plant to make the plant resistant to an herbicide like Round Up. Or we even add two genes to cause rice to make vitamin A like in \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=334\">golden rice\u003c/a>. \u003c/p>\n\u003cp>Now we aren’t always this unsophisticated. We have managed to do some \u003ca href=\"http://www.thetech.org/genetics/news.php?id=63\">pretty elegant things with genes in mice\u003c/a>. There we have tinkered with mouse genes to slightly change how they work or to control how they are expressed. \u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>But these new experiments are different. This is changing the language of life so we can make a living thing do things nothing living has yet been able to do. Maybe this is even the start of intelligent design…\u003c/p>\n\u003cp>A big reason this is all possible is because nature has given us a very simple template to work with. Not only does the genetic code have just four letters and 64, three letter words, but many of its words also have the same meaning. It is this last point that has allowed researchers to futz with the code.\u003c/p>\n\u003cp>The researchers plan to teach bacteria a new language by co-opting one of the words in the genetic code and giving it a new meaning. There are two things scientists need to do to make this happen.\u003c/p>\n\u003cp>The first is to replace all instances of one word in the bacteria’s genes with an equivalent word. Now the bacteria’s genes all still code for all the same things but a word has been freed up so it can be given a new meaning.\u003c/p>\n\u003cp>The second step is to redefine the replaced word. This will probably be done by mutating the cell’s reading machinery using some pretty well established genetic techniques.\u003c/p>\n\u003cp>Church’s group has nearly finished the first step. They managed to create four strains of bacteria each with ¼ of all 314 instances of TAG changed to TAA. They are now in the process of combining these four strains in such a way to generate a single strain with no functional TAG’s. After this first step is done (which should be soon), this group of researchers will be ready to teach these bacteria a new language.\u003c/p>\n\u003cp>An easy first thing they can do is to change the definition of the TAG so it means the same thing as one of the other words. So the TAG will no longer mean STOP but instead will mean Met or Lys or some other amino acid. (The genetic words or \u003ca href=\"http://www.thetech.org/genetics/news.php?id=118\">codons\u003c/a> really just tell a cell which amino acid to put where in a protein.) \u003c/p>\n\u003cp>Done correctly, this would probably make the bacteria immune to viral infection.* Which would be a boon for the biotech industry as it loses millions of dollars every year because of infected bacterial strains.\u003c/p>\n\u003cp>This is pretty pedestrian stuff though. The cool thing will be when they redefine TAG as a word that isn’t already in the genetic code. Then we’ll be able to easily create different proteins with properties useful as medicines, industrial enzymes or who knows what else. At least that is the hope.\u003c/p>\n\u003cp>And this is just one word. There are another 30-40 codons that may be able to be freed up and given new meanings as well. \u003c/p>\n\u003cp>We are stepping into a whole new area of research. We are retraining life to do what we want. Let’s hope we know what we’re doing…\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cem>*This is because viruses use a cell’s machinery to read its own genes. If the machinery changes, the virus will misread its own genes and die.\u003c/em>\u003c/p>\n\n","blocks":[],"excerpt":"All living things pretty much use the same language to read their genes. That is about to change. ","status":"publish","parent":0,"modified":1314127050,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":19,"wordCount":762},"headData":{"title":"Redesigning Life | KQED","description":"All living things pretty much use the same language to read their genes. That is about to change. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Redesigning Life","datePublished":"2011-08-15T17:37:43.000Z","dateModified":"2011-08-23T19:17:30.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"22140 http://science.kqed.org/quest/?p=22140","disqusUrl":"https://ww2.kqed.org/quest/2011/08/15/redesigning-life/","disqusTitle":"Redesigning Life","path":"/quest/22140/redesigning-life","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_22143\" class=\"wp-caption aligncenter\" style=\"max-width: 639px\">\u003ca href=\"http://ww2.kqed.org/quest/2011/08/15/redesigning-life/coloredbacteria/\" rel=\"attachment wp-att-22143\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/08/ColoredBacteria.jpg\" alt=\"\" title=\"ColoredBacteria\" width=\"639\" height=\"359\" class=\"size-full wp-image-22143\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2011/08/ColoredBacteria.jpg 639w, https://ww2.kqed.org/app/uploads/sites/39/2011/08/ColoredBacteria-400x225.jpg 400w\" sizes=\"(max-width: 639px) 100vw, 639px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Scientists are redesigning bacteria like these to “speak” a new language. \u003c/figcaption>\u003c/figure>\n\u003cp>All living things pretty much use the same language to read their genes. That is about to change. \u003c/p>\n\u003cp>\u003ca href=\"http://www.thetech.org/genetics/news.php?id=144\">Scientists in Boston\u003c/a> are close to teaching a strain of bacteria a new dialect of the genetic code. In combination with some work done by a different \u003ca href=\"http://www.thetech.org/genetics/news.php?id=129\">group in 2010\u003c/a>, we are now getting to the point where we can actually think about (re)designing life. Which is a big step from what we have been able to do up until now.\u003c/p>\n\u003cp>The genetic engineering we have done in the past has been pretty crude. We have mostly added pre-existing genes to cells to give the cells new properties or to have the cells make something for us. \u003c/p>\n\u003cp>So we add a human gene to bacteria so they will make insulin for us. Or we add a gene from bacteria to a plant to make the plant resistant to an herbicide like Round Up. Or we even add two genes to cause rice to make vitamin A like in \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=334\">golden rice\u003c/a>. \u003c/p>\n\u003cp>Now we aren’t always this unsophisticated. We have managed to do some \u003ca href=\"http://www.thetech.org/genetics/news.php?id=63\">pretty elegant things with genes in mice\u003c/a>. There we have tinkered with mouse genes to slightly change how they work or to control how they are expressed. \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>But these new experiments are different. This is changing the language of life so we can make a living thing do things nothing living has yet been able to do. Maybe this is even the start of intelligent design…\u003c/p>\n\u003cp>A big reason this is all possible is because nature has given us a very simple template to work with. Not only does the genetic code have just four letters and 64, three letter words, but many of its words also have the same meaning. It is this last point that has allowed researchers to futz with the code.\u003c/p>\n\u003cp>The researchers plan to teach bacteria a new language by co-opting one of the words in the genetic code and giving it a new meaning. There are two things scientists need to do to make this happen.\u003c/p>\n\u003cp>The first is to replace all instances of one word in the bacteria’s genes with an equivalent word. Now the bacteria’s genes all still code for all the same things but a word has been freed up so it can be given a new meaning.\u003c/p>\n\u003cp>The second step is to redefine the replaced word. This will probably be done by mutating the cell’s reading machinery using some pretty well established genetic techniques.\u003c/p>\n\u003cp>Church’s group has nearly finished the first step. They managed to create four strains of bacteria each with ¼ of all 314 instances of TAG changed to TAA. They are now in the process of combining these four strains in such a way to generate a single strain with no functional TAG’s. After this first step is done (which should be soon), this group of researchers will be ready to teach these bacteria a new language.\u003c/p>\n\u003cp>An easy first thing they can do is to change the definition of the TAG so it means the same thing as one of the other words. So the TAG will no longer mean STOP but instead will mean Met or Lys or some other amino acid. (The genetic words or \u003ca href=\"http://www.thetech.org/genetics/news.php?id=118\">codons\u003c/a> really just tell a cell which amino acid to put where in a protein.) \u003c/p>\n\u003cp>Done correctly, this would probably make the bacteria immune to viral infection.* Which would be a boon for the biotech industry as it loses millions of dollars every year because of infected bacterial strains.\u003c/p>\n\u003cp>This is pretty pedestrian stuff though. The cool thing will be when they redefine TAG as a word that isn’t already in the genetic code. Then we’ll be able to easily create different proteins with properties useful as medicines, industrial enzymes or who knows what else. At least that is the hope.\u003c/p>\n\u003cp>And this is just one word. There are another 30-40 codons that may be able to be freed up and given new meanings as well. \u003c/p>\n\u003cp>We are stepping into a whole new area of research. We are retraining life to do what we want. Let’s hope we know what we’re doing…\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cem>*This is because viruses use a cell’s machinery to read its own genes. If the machinery changes, the virus will misread its own genes and die.\u003c/em>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/22140/redesigning-life","authors":["6177"],"categories":["quest_4"],"tags":["quest_267","quest_9951","quest_9949","quest_1032","quest_1188","quest_1193","quest_9948","quest_9950","quest_1479","quest_13202","quest_3319"],"featImg":"quest_22143","label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? 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Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. Because everyone needs a little help being human.\u003cbr />\u003cbr />\u003ca href=\"https://www.npr.org/podcasts/510312/codeswitch\">\u003cem>Code Switch\u003c/em> offical site and podcast\u003c/a>\u003cbr />\u003ca href=\"https://www.npr.org/lifekit\">\u003cem>Life Kit\u003c/em> offical site and podcast\u003c/a>\u003cbr />","airtime":"SUN 9pm-10pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Code-Switch-Life-Kit-Podcast-Tile-360x360-1.jpg","meta":{"site":"radio","source":"npr"},"link":"/radio/program/code-switch-life-kit","subscribe":{"apple":"https://podcasts.apple.com/podcast/1112190608?mt=2&at=11l79Y&ct=nprdirectory","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93d3cubnByLm9yZy9yc3MvcG9kY2FzdC5waHA_aWQ9NTEwMzEy","spotify":"https://open.spotify.com/show/3bExJ9JQpkwNhoHvaIIuyV","rss":"https://feeds.npr.org/510312/podcast.xml"}},"commonwealth-club":{"id":"commonwealth-club","title":"Commonwealth Club of California Podcast","info":"The Commonwealth Club of California is the nation's oldest and largest public affairs forum. 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This podcast feed is usually updated twice a week and is always un-edited.","airtime":"THU 10pm, FRI 1am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Commonwealth-Club-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.commonwealthclub.org/podcasts","meta":{"site":"news","source":"Commonwealth Club of California"},"link":"/radio/program/commonwealth-club","subscribe":{"apple":"https://itunes.apple.com/us/podcast/commonwealth-club-of-california-podcast/id976334034?mt=2","google":"https://podcasts.google.com/feed/aHR0cDovL3d3dy5jb21tb253ZWFsdGhjbHViLm9yZy9hdWRpby9wb2RjYXN0L3dlZWtseS54bWw","tuneIn":"https://tunein.com/radio/Commonwealth-Club-of-California-p1060/"}},"considerthis":{"id":"considerthis","title":"Consider This","tagline":"Make sense of the day","info":"Make sense of the day. Every weekday afternoon, Consider This helps you consider the major stories of the day in less than 15 minutes, featuring the reporting and storytelling resources of NPR. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. Hosts Steve Inskeep, David Greene and Rachel Martin bring you the latest breaking news and features to prepare you for the day.","airtime":"MON-FRI 3am-9am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Morning-Edition-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/morning-edition/","meta":{"site":"news","source":"npr"},"link":"/radio/program/morning-edition"},"onourwatch":{"id":"onourwatch","title":"On Our Watch","tagline":"Police secrets, unsealed","info":"For decades, the process for how police police themselves has been inconsistent – if not opaque. In some states, like California, these proceedings were completely hidden. After a new police transparency law unsealed scores of internal affairs files, our reporters set out to examine these cases and the shadow world of police discipline. 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