Meet author Seth Mnookin at Down to a Science tonight.

Down to a Science, one of San Francisco's best monthly science events (run by our very own Kishore Hari), is back tonight to tackle the topic of vaccines and autism. Hari's events always bring together scientific experts and an engaged audience to foster an atmosphere of scientific learning.

Tonight's event features Seth Mnookin, author of The Panic Virus. From Down to a Science's website:

"In 1998 Andrew Wakefield, a British gastroenterologist with a history of self-promotion, published a paper with a shocking allegation: the measles-mumps-rubella vaccine might cause autism. The media seized hold of the story and, in the process, helped to launch one of the most devastating health scares ever. In the years to come Wakefield would be revealed as a profiteer in league with class-action lawyers, and he would eventually lose his medical license. Meanwhile one study after another failed to find any link between childhood vaccines and autism.

Yet the myth that vaccines somehow cause developmental disorders lives on. Despite the lack of corroborating evidence, it has been popularized by media personalities such as Oprah Winfrey and Jenny McCarthy.

In The Panic Virus, Seth Mnookin draws on interviews with parents, public-health advocates, scientists, and anti-vaccine activists to tackle a fundamental question: How do we decide what the truth is? The fascinating answer helps explain everything from the persistence of conspiracy theories about 9/11 to the appeal of talk-show hosts who demand that President Obama “prove” he was born in America."

Tonight's event is at the Atlas Cafe, 3049 20th St @ Alabama St. in the Mission District and runs from 7 – 9pm.

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Every Thursday, the California Academy of Sciences is transformed into a lively venue filled with music, provocative science, mingling, and cocktails for visitors 21 and older. Activities and performers change week to week. Image courtesy Jenny Oh.

Over lunch today, I got into a debate with my friend over which camp I fell into – nerd or geek. His understanding is I lacked the technical aptitude to fall into either category. Of course, I disagreed. I am quite confident that I am situated comfortably in the nerd camp. His rebuttal was that I throw parties for a living of which I countered that I throw “science” parties.

So at an impasse, definitions were in order – both are quoted form the Merriam-Webster Dictionary:

Nerd
Function: noun
Etymology: perhaps from nerd, a creature in the children's book If I Ran the Zoo (1950) by Dr. Seuss (Theodor Geisel)
An unstylish, unattractive, or socially inept person; especially one slavishly devoted to intellectual or academic pursuits

Geek
Function: noun
Etymology: probably from English dial. geek, geck fool, from Low German geck, from Middle Low German
1: a carnival performer often billed as a wild man whose act usually includes biting the head off a live chicken or snake
2: a person often of an intellectual bent who is disliked
3: an enthusiast or expert especially in a technological field or activity

“Slavishly devoted to intellectual or academic pursuits” definitely rings a bell. I love researching and I always have. In high school, the librarians knew me by name because I spent more time with books than peers. In college, I would pick paper topics specifically to gain access to the Bancroft rare books library at Cal. In school, it was easy to fuel my nerdy interests and get lost into a battle of wits amongst friends but in adulthood, I have had to search for like-minded people and events. Below is my list of favorites intellectual haunts in the city.

NightLife at California Academy of Sciences

Okay, I am totally biased as I manage the music and programming for the series. But I don’t think I would have explored so many other events if I wasn’t working on creating a “science” party of my own.

Down to a Science Informal Lectures at Atlas Café

This past Monday, I heard Brian Fisher talk about ants at this series. His stories, passion, and enthusiasm filled the room and the audience was captivated. Not only did we see into the fascinating world of ants but we found out why Dr. Fisher screens his calls. His number one question from the public is ‘How do I get rid of the ants in my kitchen?’

Down to a Science Book Club at Book Inc.

In January, we are reading Dr. Tatiana’s Sex Advice for all Creation which is one of my all-time favorite science books. In the past month, I was introduced to the amazing medical mystery of Prions. The discussion has been small and incredibly lively each time I’ve attended.

Exploratorium after Dark

Okay, I have to admit that I haven’t been to this particular event yet because I work on NightLife on Thursday nights. But I have a group assembled to go check it out during our hiatus in December. I love that they are doing a night like this as I HEART the Exploratorium. I have ever since I visited during bubble day and was able to step into a giant bubble thanks to a lot of bubble solution and a simple pulley system.

LoveTech usually held at Il Pirata

I attended LearnTech which is a part of this series to support my friend who built a navigation portal into fractals. This is a great event that plays with the intersection between art, electronics and music. LearnTech was set up as mini talks and tabling. The talks, interaction, and boundless creativity had me captivated.

Ask a Scientist Informal Lectures held at Axis Café

This is another informal Science Café that has great content. The last one I was able to attend delved into the science behind magic. Even thought the place was packed, the lecture and discussion were lively and funny to boot.

Bookswap held at Booksmith

Reading, being my portal into nerdiness, is a constant pastime. But there are very few times that I get to truly discuss a book let alone several. I brought Mary Roach’s Bonk and swapped it for a Ninja novel. I was also given the recommendation of World War Z. I read it in two days; itt was so well written and absolutely engrossing.

What’s wonderful about San Francisco is this is only a slice of science events in the city. Have you found a haunt in the San Francisco Science Scene? Feel free to share you’re favorites in the comment section below.

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Prion diseases are neurodegenerative, attacking the brain. Could they be responsible for the recent wave of Zombie attacks across the globe? Original photo: digitalsextant.

But what if there existed a substance that acted like a virus or bacteria but wasn’t living? Medicine made a revolutionary leap during the time of Louis Pasteur in the mid 1800's. The inventor of food pasteurization and one of the founding fathers of microbiology – he was able to prove germ theory. Food spoiled and organisms got sick because of the growth of bacteria and viruses within them. Within sterile environments, viruses and bacteria could be killed off and food could be preserved or organisms could recover from illness or infection. Sterilization works on living micro-organisms. Prions, however, are not living organisms.

Prions are infectious proteins. For unknown reasons, these proteins refold abnormally and cause a domino effect in surrounding proteins which in turn mutate into stable structures. Prions will then cause tissue damage and cell death to surrounding areas. Prion diseases are neurodegenerative, attacking the brain and are characterized by "holes" in the tissue. The incubation time for Prion diseases is quite long. They usually surface later in life but after they surface, the diseases are rapid and fatal. Such examples of Prion diseases include Mad Cow Disease in cattle, Scrapie in sheep and Fatal Familial Insomnia in humans. FFI is a disease that literally takes away the ability to sleep and in a few months leads to death. The Book “The Family That Couldn’t Sleep” by journalist D.T. Max follows a family in Italy that passes this disease from one generation to the next over subsequent centuries.

Prions have been and still are a medical mystery. What causes them to mutate and aggressively eat away at the brain? How can they be stopped? Because they are not living they are highly resistant to sterilization methods. While viruses and bacteria can be eradicated on equipment through heat, radiation or chemical reagents, Prions are strongly immune. Maybe Zombies are not so far off after all – lurking in the shadow of medicine has been a mutation that is resistant, brain-eating and neither alive or dead. It has some serious similarities to the zombies I have watched over and over again on the big screen.

If you want to learn more about Prions and their history, check out Down to a Science’s next reading group which is focusing on the book The Family that Couldn’t Sleep or check out the book Deadly Feasts: The "Prion" Controversy and the Public's Health by Richard Rhodes. And one more thing – Happy Halloween!

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David experimenting with EEG

David takes “guinea pig” journalism to super size me heights. He was tested by numerous genetic sequencing companies, had dozens of brain scans, gave gallons of blood for toxicity tests, even had a virtual colonoscopy to understand what “personalized” medicine means for him. His experimentation was divided into 4 categories: genetics, environment, brain, and body.

My favorite experiment was a memory test in which David and I both participated. The study was on how normal aging changes the neural mechanisms of memory and attention; a study run by Dr. Adam Gazzaley of UCSF. His lab uses a combination of techniques including fMRI (functional magnetic resonance imaging -measures blood flow using a big magnet), EEG (electroencephalography – measures electrical signals in the brain), and TMS (transcranial magnetic stimulation – using a magnet to “scramble” regions of the brain).

In this experiment, I was getting an EEG, designed to measure electrical signals of the brain, in this case studying regions controlling memory and attention. I was fitted with a stylish red cap, my head was covered with a conductive gel, and I was seated a few feet from a computer screen. After some careful measurements of my head, I was ready to go.

I was shown either a face or nature scene for a split second, then the screen went blank, then I was shown another face or nature scene. My task was to decide whether the two pictures were the same. Sounds exceedingly simple, but it was far from it. I left absolutely exhausted after just a few hours!

However, my results were excellent. I averaged about 95% correct over 3 hours. According to the researchers, that’s slightly better than the average 18-35 year old. David’s results were about the same, but he is more enthusiastic considering he’s closer to 50. Take a simpler version of a brain age test online.

The Experimental Man with David Ewing Duncan

Where: Atlas Cafe, 3049 20th St @ Alabama St.

When: Monday, October 19th 7-9 PM

Cost: FREE

Details: David Ewing Duncan discusses his new book “The Experimental Man”, his book exploring what cutting-edge technologies in personalized medicine can tell us about individual health and life — past, present and future: genes, environment, brain and body.

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