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Barry Starr","firstName":"Dr. Barry","lastName":"Starr","slug":"dr-barry-starr","email":"bstarr@thetech.org","display_author_email":false,"staff_mastheads":[],"title":null,"bio":"Dr. Barry Starr (\u003ca href=\"https://twitter.com/geneticsboy\">@geneticsboy\u003c/a>) is a Geneticist-in-Residence at The Tech Museum of Innovation in San Jose, CA and runs their Stanford at The Tech program. The program is part of an ongoing collaboration between the \u003ca href=\"http://genetics.stanford.edu/\">Stanford Department of Genetics\u003c/a> and \u003ca href=\"http://www.thetech.org/\">The Tech Museum of Innovation\u003c/a>. Together these two partners created the \u003ca href=\"http://www.thetech.org/exhibits/permanent/index.php?sGalKey=gtwt&galKey=lt\">Genetics: Technology with a Twist\u003c/a> exhibition.\r\n\r\nYou can also see \u003ca href=\"https://ww2.kqed.org/science/author/dr-barry-starr/\">additional posts by Barry at KQED Science\u003c/a>, and read his \u003ca href=\"http://science.kqed.org/quest/author/dr-barry-starr/\">previous contributions\u003c/a> to \u003ca href=\"http://science.kqed.org/quest/\">QUEST\u003c/a>, a project dedicated to exploring the Science of Sustainability.","avatar":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g","twitter":"geneticsboy","facebook":null,"instagram":null,"linkedin":null,"sites":[{"site":"science","roles":["author"]},{"site":"quest","roles":["subscriber"]}],"headData":{"title":"Dr. Barry Starr | KQED","description":null,"ogImgSrc":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g","twImgSrc":"https://secure.gravatar.com/avatar/4a5680e4c642ea0f0f3041af16018969?s=600&d=blank&r=g"},"isLoading":false,"link":"/author/dr-barry-starr"}},"breakingNewsReducer":{},"campaignFinanceReducer":{},"firebase":{"requesting":{},"requested":{},"timestamps":{},"data":{},"ordered":{},"auth":{"isLoaded":false,"isEmpty":true},"authError":null,"profile":{"isLoaded":false,"isEmpty":true},"listeners":{"byId":{},"allIds":[]},"isInitializing":false,"errors":[]},"navBarReducer":{"navBarId":"home","fullView":true,"showPlayer":false},"navMenuReducer":{"menus":[{"key":"menu1","items":[{"name":"News","link":"/","type":"title"},{"name":"Politics","link":"/politics"},{"name":"Science","link":"/science"},{"name":"Education","link":"/educationnews"},{"name":"Housing","link":"/housing"},{"name":"Immigration","link":"/immigration"},{"name":"Criminal Justice","link":"/criminaljustice"},{"name":"Silicon Valley","link":"/siliconvalley"},{"name":"Forum","link":"/forum"},{"name":"The California Report","link":"/californiareport"}]},{"key":"menu2","items":[{"name":"Arts & Culture","link":"/arts","type":"title"},{"name":"Critics’ Picks","link":"/thedolist"},{"name":"Cultural Commentary","link":"/artscommentary"},{"name":"Food & Drink","link":"/food"},{"name":"Bay Area Hip-Hop","link":"/bayareahiphop"},{"name":"Rebel Girls","link":"/rebelgirls"},{"name":"Arts Video","link":"/artsvideos"}]},{"key":"menu3","items":[{"name":"Podcasts","link":"/podcasts","type":"title"},{"name":"Bay Curious","link":"/podcasts/baycurious"},{"name":"Rightnowish","link":"/podcasts/rightnowish"},{"name":"The Bay","link":"/podcasts/thebay"},{"name":"On Our Watch","link":"/podcasts/onourwatch"},{"name":"Mindshift","link":"/podcasts/mindshift"},{"name":"Consider This","link":"/podcasts/considerthis"},{"name":"Political Breakdown","link":"/podcasts/politicalbreakdown"}]},{"key":"menu4","items":[{"name":"Live Radio","link":"/radio","type":"title"},{"name":"TV","link":"/tv","type":"title"},{"name":"Events","link":"/events","type":"title"},{"name":"For Educators","link":"/education","type":"title"},{"name":"Support KQED","link":"/support","type":"title"},{"name":"About","link":"/about","type":"title"},{"name":"Help Center","link":"https://kqed-helpcenter.kqed.org/s","type":"title"}]}]},"pagesReducer":{},"postsReducer":{"stream_live":{"type":"live","id":"stream_live","audioUrl":"https://streams.kqed.org/kqedradio","title":"Live Stream","excerpt":"Live Stream information currently unavailable.","link":"/radio","featImg":"","label":{"name":"KQED Live","link":"/"}},"stream_kqedNewscast":{"type":"posts","id":"stream_kqedNewscast","audioUrl":"https://www.kqed.org/.stream/anon/radio/RDnews/newscast.mp3?_=1","title":"KQED Newscast","featImg":"","label":{"name":"88.5 FM","link":"/"}},"quest_36278":{"type":"posts","id":"quest_36278","meta":{"index":"posts_1591205157","site":"quest","id":"36278","score":null,"sort":[1335800369000]},"guestAuthors":[],"slug":"desperately-seeking-autism-genes","title":"Desperately Seeking Autism Genes","publishDate":1335800369,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cfigure id=\"attachment_36281\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/04/30/desperately-seeking-autism-genes/xychrom/\" rel=\"attachment wp-att-36281\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/XYchrom.jpg\" alt=\"\" title=\"XYchrom\" width=\"640\" height=\"390\" class=\"size-full wp-image-36281\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/04/XYchrom.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2012/04/XYchrom-400x244.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Brand new mutations are helping scientists figure out what is going on in autism.\u003c/figcaption>\u003c/figure>\n\u003cp>Autism is incredibly frustrating from a genetic point of view. Every study clearly shows that genetics plays an important role in this disease. But when these studies try to find a cause, they keep coming up short.\u003c/p>\n\u003cp>And this isn’t because scientists aren’t trying hard. They are. In most of the recent studies they are comparing thousands of people’s DNA at millions of different spots. If there was a simple explanation, they would have found it.\u003c/p>\n\u003cp>One thing they have managed to find from all of these studies is that a minority of cases result from \u003ca href=\"http://www.thetech.org/genetics/news.php?id=49\">brand new mutations\u003c/a> that most likely happen in either the sperm or the egg before fertilization. While these are not going to be that useful as a diagnostic test, they may prove useful as a way of figuring out which genes to focus on. And maybe even for coming up with new ways to treat autism.\u003c/p>\n\u003cp>With that in mind, a whole slew of researchers set out to find more of these sorts of \u003cem>de novo\u003c/em> mutations (as they are called). They reported their findings in the following three back to back to back reports in the journal \u003cem>Nature\u003c/em>:\u003c/p>\n\u003cp>\u003ca href=\"http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11011.html\">Study 1\u003c/a>\u003cbr>\n\u003ca href=\"http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10989.html\">Study 2\u003c/a>\u003cbr>\n\u003ca href=\"http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10945.html\">Study 3\u003c/a>\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>These researchers took on the herculean task of looking at every letter of every gene of over two thousand people. Basically they compared the genes of parents to the genes of their autistic children (and a few of their unaffected siblings). They were able to confirm that some previously identified genes were important in autism and they identified a few new ones. \u003c/p>\n\u003cp>They were also able to confirm that older dads pass on more of these sorts of mutations than younger dads or moms of any age. Which makes sense if you think about sperm production.\u003c/p>\n\u003cp>Each time a sperm is made, its DNA needs to get copied. And each time DNA is copied, there is a chance for a mistake to creep in. So it makes sense that the older the dad, the more mutations he’ll have in his sperm.\u003c/p>\n\u003cp>Frustratingly, this was the most solid finding in the study. But fret not. They also learned some important things about how autism happens too.\u003c/p>\n\u003cp>The most important thing they found was that many children with autism shared mutations in related genes. Their mutations affected different genes that all impacted the same or related biochemical pathways.\u003c/p>\n\u003cfigure id=\"attachment_36297\" class=\"wp-caption alignright\" style=\"max-width: 250px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/04/30/desperately-seeking-autism-genes/autisticbrain2/\" rel=\"attachment wp-att-36297\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/autisticBrain2.jpg\" alt=\"\" title=\"autisticBrain2\" width=\"250\" height=\"158\" class=\"size-full wp-image-36297\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">An fMRI scan of an autistic brain.\u003c/figcaption>\u003c/figure>\n\u003cp>This is what we might expect from something as complicated as brain development. To pull off something like this, various genes are going to need to fire off at the right time in the right order. If any one of the genes in a similar pathway misfires, you can end up with similar problems. And this is undoubtedly happening in some cases of autism.\u003c/p>\n\u003cp>This is a very important finding for identifying where to focus research so new treatments can be found for this disease. Isolated genes can be hard to target because sometimes scientists don’t know what they are doing or how they fit into the grand scheme of things. But researchers can identify a pathway, then they can identify chemicals that can tweak that pathway that can one day become medicines.\u003c/p>\n\u003cp>These studies also highlight yet again what a hideously complex disease autism is. Your risk depends on what versions of lots of different genes you have. Some versions will increase your risk and some will decrease it. Your chances are a summation of all of these risks.\u003c/p>\n\u003cp>As if this wasn’t complicated enough, autism is more than genes. Something \u003ca href=\"http://ww2.kqed.org/quest/2011/07/18/autism-more-than-genes/\">in the environment\u003c/a> has to trigger the disease and we know very little about these triggers (except that vaccines aren’t one). Now add to this the fact that different genetic combinations are going to be susceptible to different triggers and you begin to see why this has been such a challenge to geneticists. \u003c/p>\n\u003cp>Figuring out why a particular person ended up with autism is really hard. But even if we can’t figure it out for a particular person, these studies are important for finding what is happening in the brains of people with autism. And hopefully by knowing that, we can find new treatments.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>[youtube=http://www.youtube.com/watch?v=MM-x25z-i7w]\u003cbr>\n\u003cem>\u003cbr>\nA long video about the biology of autism. Well worth your time.\u003c/em>\u003c/p>\n\n","blocks":[],"excerpt":"Autism is incredibly frustrating from a genetic point of view. Every study clearly shows that genetics plays an important role in this disease. But when these studies try to find a cause, they keep coming up short.","status":"publish","parent":0,"modified":1336072658,"stats":{"hasAudio":false,"hasVideo":true,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":18,"wordCount":754},"headData":{"title":"Desperately Seeking Autism Genes | KQED","description":"Autism is incredibly frustrating from a genetic point of view. Every study clearly shows that genetics plays an important role in this disease. But when these studies try to find a cause, they keep coming up short.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Desperately Seeking Autism Genes","datePublished":"2012-04-30T15:39:29.000Z","dateModified":"2012-05-03T19:17:38.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"36278 http://science.kqed.org/quest/?p=36278","disqusUrl":"https://ww2.kqed.org/quest/2012/04/30/desperately-seeking-autism-genes/","disqusTitle":"Desperately Seeking Autism Genes","path":"/quest/36278/desperately-seeking-autism-genes","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_36281\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/04/30/desperately-seeking-autism-genes/xychrom/\" rel=\"attachment wp-att-36281\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/XYchrom.jpg\" alt=\"\" title=\"XYchrom\" width=\"640\" height=\"390\" class=\"size-full wp-image-36281\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/04/XYchrom.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2012/04/XYchrom-400x244.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Brand new mutations are helping scientists figure out what is going on in autism.\u003c/figcaption>\u003c/figure>\n\u003cp>Autism is incredibly frustrating from a genetic point of view. Every study clearly shows that genetics plays an important role in this disease. But when these studies try to find a cause, they keep coming up short.\u003c/p>\n\u003cp>And this isn’t because scientists aren’t trying hard. They are. In most of the recent studies they are comparing thousands of people’s DNA at millions of different spots. If there was a simple explanation, they would have found it.\u003c/p>\n\u003cp>One thing they have managed to find from all of these studies is that a minority of cases result from \u003ca href=\"http://www.thetech.org/genetics/news.php?id=49\">brand new mutations\u003c/a> that most likely happen in either the sperm or the egg before fertilization. While these are not going to be that useful as a diagnostic test, they may prove useful as a way of figuring out which genes to focus on. And maybe even for coming up with new ways to treat autism.\u003c/p>\n\u003cp>With that in mind, a whole slew of researchers set out to find more of these sorts of \u003cem>de novo\u003c/em> mutations (as they are called). They reported their findings in the following three back to back to back reports in the journal \u003cem>Nature\u003c/em>:\u003c/p>\n\u003cp>\u003ca href=\"http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11011.html\">Study 1\u003c/a>\u003cbr>\n\u003ca href=\"http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10989.html\">Study 2\u003c/a>\u003cbr>\n\u003ca href=\"http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10945.html\">Study 3\u003c/a>\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>These researchers took on the herculean task of looking at every letter of every gene of over two thousand people. Basically they compared the genes of parents to the genes of their autistic children (and a few of their unaffected siblings). They were able to confirm that some previously identified genes were important in autism and they identified a few new ones. \u003c/p>\n\u003cp>They were also able to confirm that older dads pass on more of these sorts of mutations than younger dads or moms of any age. Which makes sense if you think about sperm production.\u003c/p>\n\u003cp>Each time a sperm is made, its DNA needs to get copied. And each time DNA is copied, there is a chance for a mistake to creep in. So it makes sense that the older the dad, the more mutations he’ll have in his sperm.\u003c/p>\n\u003cp>Frustratingly, this was the most solid finding in the study. But fret not. They also learned some important things about how autism happens too.\u003c/p>\n\u003cp>The most important thing they found was that many children with autism shared mutations in related genes. Their mutations affected different genes that all impacted the same or related biochemical pathways.\u003c/p>\n\u003cfigure id=\"attachment_36297\" class=\"wp-caption alignright\" style=\"max-width: 250px\">\u003ca href=\"http://ww2.kqed.org/quest/2012/04/30/desperately-seeking-autism-genes/autisticbrain2/\" rel=\"attachment wp-att-36297\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/04/autisticBrain2.jpg\" alt=\"\" title=\"autisticBrain2\" width=\"250\" height=\"158\" class=\"size-full wp-image-36297\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">An fMRI scan of an autistic brain.\u003c/figcaption>\u003c/figure>\n\u003cp>This is what we might expect from something as complicated as brain development. To pull off something like this, various genes are going to need to fire off at the right time in the right order. If any one of the genes in a similar pathway misfires, you can end up with similar problems. And this is undoubtedly happening in some cases of autism.\u003c/p>\n\u003cp>This is a very important finding for identifying where to focus research so new treatments can be found for this disease. Isolated genes can be hard to target because sometimes scientists don’t know what they are doing or how they fit into the grand scheme of things. But researchers can identify a pathway, then they can identify chemicals that can tweak that pathway that can one day become medicines.\u003c/p>\n\u003cp>These studies also highlight yet again what a hideously complex disease autism is. Your risk depends on what versions of lots of different genes you have. Some versions will increase your risk and some will decrease it. Your chances are a summation of all of these risks.\u003c/p>\n\u003cp>As if this wasn’t complicated enough, autism is more than genes. Something \u003ca href=\"http://ww2.kqed.org/quest/2011/07/18/autism-more-than-genes/\">in the environment\u003c/a> has to trigger the disease and we know very little about these triggers (except that vaccines aren’t one). Now add to this the fact that different genetic combinations are going to be susceptible to different triggers and you begin to see why this has been such a challenge to geneticists. \u003c/p>\n\u003cp>Figuring out why a particular person ended up with autism is really hard. But even if we can’t figure it out for a particular person, these studies are important for finding what is happening in the brains of people with autism. And hopefully by knowing that, we can find new treatments.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutube'>\n \u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutubeInside'>\n \u003ciframe\n loading='lazy'\n class='utils-parseShortcode-shortcodes-__youtubeShortcode__youtubePlayer'\n type='text/html'\n src='//www.youtube.com/embed/MM-x25z-i7w'\n title='//www.youtube.com/embed/MM-x25z-i7w'\n allowfullscreen='true'\n style='border:0;'>\u003c/iframe>\n \u003c/span>\n \u003c/span>\u003c/p>\u003cp>\u003cbr>\n\u003cem>\u003cbr>\nA long video about the biology of autism. Well worth your time.\u003c/em>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/36278/desperately-seeking-autism-genes","authors":["6177"],"categories":["quest_4"],"tags":["quest_256","quest_11031","quest_11030","quest_1197","quest_1900","quest_13202","quest_2684","quest_3319"],"featImg":"quest_36281","label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? 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Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. Hosts Steve Inskeep, David Greene and Rachel Martin bring you the latest breaking news and features to prepare you for the day.","airtime":"MON-FRI 3am-9am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Morning-Edition-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/morning-edition/","meta":{"site":"news","source":"npr"},"link":"/radio/program/morning-edition"},"onourwatch":{"id":"onourwatch","title":"On Our Watch","tagline":"Police secrets, unsealed","info":"For decades, the process for how police police themselves has been inconsistent – if not opaque. In some states, like California, these proceedings were completely hidden. After a new police transparency law unsealed scores of internal affairs files, our reporters set out to examine these cases and the shadow world of police discipline. 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