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The conference begins July 23\u003csup>rd\u003c/sup> in Washington D.C. One of the topics sure to be high on the agenda is: Where are we with a cure? More than 34 million people are living with HIV/AIDS worldwide, but only one person has apparently been cured of the virus.\u003c/em>\u003c/p>\n\u003cp>\u003cem>\u003ca href=\"https://ww2.kqed.org/quest/author/amystanden/\">Amy Standen\u003c/a> spoke with the man known in some research circles as \u003cstrong>“the Berlin Patient.”\u003c/strong>\u003c/em>\u003c/p>\n\u003cp>\u003cstrong>THE BERLIN PATIENT\u003c/strong>\u003c/p>\n\u003cfigure id=\"attachment_41219\" class=\"wp-caption alignleft\" style=\"max-width: 160px\">\u003cimg class=\"size-full wp-image-41219 \" title=\"brown_160\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/07/brown_160.jpg\" alt=\"\" width=\"160\" height=\"160\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/07/brown_160.jpg 160w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/brown_160-32x32.jpg 32w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/brown_160-64x64.jpg 64w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/brown_160-96x96.jpg 96w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/brown_160-128x128.jpg 128w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/brown_160-75x75.jpg 75w\" sizes=\"(max-width: 160px) 100vw, 160px\">\u003cfigcaption class=\"wp-caption-text\">Timothy Brown (photo: timothyrbrown.com)\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>\u003ca href=\"http://timothyrbrown.com/\">Timothy Ray Brown\u003c/a>\u003c/strong> was diagnosed with HIV in 1995, when he was living in Berlin. Nine years later, still in Germany, he received another devastating diagnosis: leukemia.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>His doctor there had a novel idea. Maybe he could treat both diseases at once, by giving Brown a bone marrow transplant from a very specific type of donor, one who was CCR5 negative.\u003c/p>\n\u003cp>“It took 67 tries to find the right person,” says Brown.\u003c/p>\n\u003cp>The CCR5 mutation turns up in about one percent of Northern European descendants. It makes them naturally resistant to HIV infection.\u003c/p>\n\u003cp>Brown received two bone marrow transplants, one in 2007 and one in 2008, both from the same donor. The procedures were arduous, with lasting complications. But they also left Brown with a new immune system.\u003c/p>\n\u003cp>Brown, who is 46 and now lives in San Francisco, has apparently been free of the virus for about five years, and takes no HIV medications. Meanwhile, he’s watched friends die of the disease he no longer has.\u003c/p>\n\u003cp>“Being the only one in the world... I kind of have a slight guilt feeling about it,” he says.\u003c/p>\n\u003cp>Brown says he knows his treatment was risky and expensive, and that many researchers believe it's not a practical response to the worldwide AIDS epidemic. But he’s counting on science to change that.\u003c/p>\n\u003cp>Says Brown, “I’m hoping that when, and if, there is a cure it can be administered to the entire world. And I think that’s going to happen. I’m hoping for it.\"\u003c/p>\n\u003cp>\u003cstrong>THE TOOLS OF GENETIC ENGINEERING\u003cbr>\n\u003c/strong>\u003c/p>\n\u003cp>\u003cem>California researchers are trying to replicate Timothy Brown’s treatment through a controversial gene therapy technique using stem cells. \u003ca href=\"http://ww2.kqed.org/quest/author/andrea-kissack/\">Andrea Kissack\u003c/a> spoke with one of those scientists, \u003cstrong>\u003ca href=\"http://pibbs.usc.edu/faculty/profile/?fid=186\">Paula Cannon\u003c/a>,\u003c/strong> a microbiologist at the University of Southern California.\u003c/em>\u003c/p>\n\u003cfigure id=\"attachment_41200\" class=\"wp-caption alignleft\" style=\"max-width: 160px\">\u003cimg class=\"size-full wp-image-41200\" title=\"Cannon_160\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/07/Cannon_160.jpg\" alt=\"\" width=\"160\" height=\"160\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/07/Cannon_160.jpg 160w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/Cannon_160-32x32.jpg 32w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/Cannon_160-64x64.jpg 64w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/Cannon_160-96x96.jpg 96w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/Cannon_160-128x128.jpg 128w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/Cannon_160-75x75.jpg 75w\" sizes=\"(max-width: 160px) 100vw, 160px\">\u003cfigcaption class=\"wp-caption-text\">Paula Cannon, Keck School of Medicine, University of Southern California (photo: USC)\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>You have been working with a technique that has proved successful in mice and will soon be expanding into human trials. How are you trying to replicate the apparent cure that has happened for Timothy Brown?\u003c/strong>\u003c/p>\n\u003cp>What we don’t want to have to do is do the same procedure that Timothy underwent. So let’s instead, how about the idea of taking some bone marrow stem cells from an AIDS patient, and engineering them so that we can make some of them also HIV resistant?\u003c/p>\n\u003cp>And the idea is we can do that, because now we have the genetic tools that allow us to go in and find the CCR5 gene in those stem cells and basically, like using a pair of scissors, we can cut it out. And then asking whether those cells that are now HIV resistant are gonna be powerful enough to actually sort of stop HIV in its tracks in patients.\u003c/p>\n\u003cp>\u003cstrong>So you are taking stem cells from patients and cutting out one protein and then putting the cells back, through a method like an IV?\u003c/strong>\u003c/p>\n\u003cp>Yes, we're trying to do the poor man’s version of what happened to Timothy Ray Brown. We’re going to use the tools of genetic engineering to snip out the CCR5 gene in a patient’s own cells, and in that way make some part of their immune system be resistant to HIV.\u003c/p>\n\u003cp>\u003cstrong>Last month there were some reports that Timothy Brown may not be virus free. What do you think about that? Is there a disagreement over detection levels or are there different kinds of cures?\u003c/strong>\u003c/p>\n\u003cp>By my definition of a cure which is for five years now he has had no replicating virus in his body, he is not able to infect anybody and he doesn’t have to take drugs. He is cured as far as I am concerned. If you want to get into semantics, one of the things that scientists are curious about is did we manage to remove every last trace of virus from his body or does he have some bits of dead virus floating around? I guess if you look long enough and hard enough – absolutely, we would find some traces of HIV. Importantly, if we are trying to develop ways to take lessons that happened to Timothy, and develop a treatment that can be given to people without needing a bone marrow transplant, to my mind the best possible outcome is that we find that Timothy still has these little remnants of HIV but despite that he is able to control it and he has cured himself through having this HIV resistant immune system.\u003c/p>\n\u003cp>\u003cstrong>You are using funds from the California Stem Cell Bond to help with this research?\u003c/strong>\u003c/p>\n\u003cp>That’s correct, and that’s been really, really important. When we first started this sort of work, we were doing it in collaboration with a biotech company in the Bay Area. And we were able to go to the California Institute of Regenerative Medicine, which is the agency that was set up after the stem cell initiative in 2004.\u003c/p>\n\u003cp>We were able to persuade them, I think, not just that in this way we could be using stem cells to really deliver a therapy to HIV-positive people, but also that the sort of techniques that we were developing in this way are going to have applications beyond HIV.\u003c/p>\n\u003cp>\u003cstrong>One of the challenges with stem cell therapy is the high cost of research and the distant payoff for the whole thing. So you are going to start the human trials in 2014 – what are you looking at in terms of seeing some signs if some of this gene therapy is working?\u003c/strong>\u003c/p>\n\u003cp>We have a series of benchmarks that we would look for. First of all, do we see any evidence that the CCR-5 negative cells are appearing in the patients after we give them the stem cells back? Are the levels of these cells increasing, which would suggest they have a selective advantage in the body?\u003c/p>\n\u003cp>We hope, of course, to end up with the situation, as happened with Timothy, whereby we can take the patients off the drugs, and they are themselves able to suppress and control the virus. I think for me, I’m very optimistic about it, because what we’re talking about are new types of medicine – gene therapies, cellular therapies – and we certainly don’t have the processes in place to make this cheap and easy yet. But I happen to believe that that’s just an engineering problem.\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>If this works, if these sort of therapies can really allow people to live without taking drugs and to cure themselves of HIV, there’s gonna be such excitement about this, such a big effort into figuring out how to do it at scale, to do it cheaply. We’re just gonna invent whole different ways of doing medicine.\u003c/p>\n\n","blocks":[],"excerpt":"More than 34 million people live with HIV/AIDS worldwide but only one person may have been cured of the virus. We look at promising, genetic research that is aimed at replicating this apparent cure.","status":"publish","parent":0,"modified":1443825091,"stats":{"hasAudio":true,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":30,"wordCount":1301},"headData":{"title":"A Unique HIV Case Inspires New Research | KQED","description":"More than 34 million people live with HIV/AIDS worldwide but only one person may have been cured of the virus. We look at promising, genetic research that is aimed at replicating this apparent cure.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"A Unique HIV Case Inspires New Research","datePublished":"2012-07-20T18:31:48.000Z","dateModified":"2015-10-02T22:31:31.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"41171 http://science.kqed.org/quest/?post_type=audio_reports&p=41171","disqusUrl":"https://ww2.kqed.org/quest/2012/07/20/a-unique-hiv-case-inspires-new-research/","disqusTitle":"A Unique HIV Case Inspires New Research","path":"/quest/41171/a-unique-hiv-case-inspires-new-research","audioUrl":"http://www.kqed.org/.stream/anon/radio/quest/2012/07/2012-07-23-quest.mp3","audioDuration":null,"audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>http://www.kqed.org/.stream/anon/radio/quest/2012/07/2012-07-23-quest.mp3\u003c/p>\n\u003cp>\u003cem>For the first time in more than 20 years, the International AIDS Conference is being held in the U.S. In 2010, President Obama lifted a more than two decade old travel ban on HIV positive people entering the country. The conference begins July 23\u003csup>rd\u003c/sup> in Washington D.C. One of the topics sure to be high on the agenda is: Where are we with a cure? More than 34 million people are living with HIV/AIDS worldwide, but only one person has apparently been cured of the virus.\u003c/em>\u003c/p>\n\u003cp>\u003cem>\u003ca href=\"https://ww2.kqed.org/quest/author/amystanden/\">Amy Standen\u003c/a> spoke with the man known in some research circles as \u003cstrong>“the Berlin Patient.”\u003c/strong>\u003c/em>\u003c/p>\n\u003cp>\u003cstrong>THE BERLIN PATIENT\u003c/strong>\u003c/p>\n\u003cfigure id=\"attachment_41219\" class=\"wp-caption alignleft\" style=\"max-width: 160px\">\u003cimg class=\"size-full wp-image-41219 \" title=\"brown_160\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/07/brown_160.jpg\" alt=\"\" width=\"160\" height=\"160\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/07/brown_160.jpg 160w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/brown_160-32x32.jpg 32w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/brown_160-64x64.jpg 64w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/brown_160-96x96.jpg 96w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/brown_160-128x128.jpg 128w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/brown_160-75x75.jpg 75w\" sizes=\"(max-width: 160px) 100vw, 160px\">\u003cfigcaption class=\"wp-caption-text\">Timothy Brown (photo: timothyrbrown.com)\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>\u003ca href=\"http://timothyrbrown.com/\">Timothy Ray Brown\u003c/a>\u003c/strong> was diagnosed with HIV in 1995, when he was living in Berlin. Nine years later, still in Germany, he received another devastating diagnosis: leukemia.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>His doctor there had a novel idea. Maybe he could treat both diseases at once, by giving Brown a bone marrow transplant from a very specific type of donor, one who was CCR5 negative.\u003c/p>\n\u003cp>“It took 67 tries to find the right person,” says Brown.\u003c/p>\n\u003cp>The CCR5 mutation turns up in about one percent of Northern European descendants. It makes them naturally resistant to HIV infection.\u003c/p>\n\u003cp>Brown received two bone marrow transplants, one in 2007 and one in 2008, both from the same donor. The procedures were arduous, with lasting complications. But they also left Brown with a new immune system.\u003c/p>\n\u003cp>Brown, who is 46 and now lives in San Francisco, has apparently been free of the virus for about five years, and takes no HIV medications. Meanwhile, he’s watched friends die of the disease he no longer has.\u003c/p>\n\u003cp>“Being the only one in the world... I kind of have a slight guilt feeling about it,” he says.\u003c/p>\n\u003cp>Brown says he knows his treatment was risky and expensive, and that many researchers believe it's not a practical response to the worldwide AIDS epidemic. But he’s counting on science to change that.\u003c/p>\n\u003cp>Says Brown, “I’m hoping that when, and if, there is a cure it can be administered to the entire world. And I think that’s going to happen. I’m hoping for it.\"\u003c/p>\n\u003cp>\u003cstrong>THE TOOLS OF GENETIC ENGINEERING\u003cbr>\n\u003c/strong>\u003c/p>\n\u003cp>\u003cem>California researchers are trying to replicate Timothy Brown’s treatment through a controversial gene therapy technique using stem cells. \u003ca href=\"http://ww2.kqed.org/quest/author/andrea-kissack/\">Andrea Kissack\u003c/a> spoke with one of those scientists, \u003cstrong>\u003ca href=\"http://pibbs.usc.edu/faculty/profile/?fid=186\">Paula Cannon\u003c/a>,\u003c/strong> a microbiologist at the University of Southern California.\u003c/em>\u003c/p>\n\u003cfigure id=\"attachment_41200\" class=\"wp-caption alignleft\" style=\"max-width: 160px\">\u003cimg class=\"size-full wp-image-41200\" title=\"Cannon_160\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2012/07/Cannon_160.jpg\" alt=\"\" width=\"160\" height=\"160\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2012/07/Cannon_160.jpg 160w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/Cannon_160-32x32.jpg 32w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/Cannon_160-64x64.jpg 64w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/Cannon_160-96x96.jpg 96w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/Cannon_160-128x128.jpg 128w, https://ww2.kqed.org/app/uploads/sites/39/2012/07/Cannon_160-75x75.jpg 75w\" sizes=\"(max-width: 160px) 100vw, 160px\">\u003cfigcaption class=\"wp-caption-text\">Paula Cannon, Keck School of Medicine, University of Southern California (photo: USC)\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>You have been working with a technique that has proved successful in mice and will soon be expanding into human trials. How are you trying to replicate the apparent cure that has happened for Timothy Brown?\u003c/strong>\u003c/p>\n\u003cp>What we don’t want to have to do is do the same procedure that Timothy underwent. So let’s instead, how about the idea of taking some bone marrow stem cells from an AIDS patient, and engineering them so that we can make some of them also HIV resistant?\u003c/p>\n\u003cp>And the idea is we can do that, because now we have the genetic tools that allow us to go in and find the CCR5 gene in those stem cells and basically, like using a pair of scissors, we can cut it out. And then asking whether those cells that are now HIV resistant are gonna be powerful enough to actually sort of stop HIV in its tracks in patients.\u003c/p>\n\u003cp>\u003cstrong>So you are taking stem cells from patients and cutting out one protein and then putting the cells back, through a method like an IV?\u003c/strong>\u003c/p>\n\u003cp>Yes, we're trying to do the poor man’s version of what happened to Timothy Ray Brown. We’re going to use the tools of genetic engineering to snip out the CCR5 gene in a patient’s own cells, and in that way make some part of their immune system be resistant to HIV.\u003c/p>\n\u003cp>\u003cstrong>Last month there were some reports that Timothy Brown may not be virus free. What do you think about that? Is there a disagreement over detection levels or are there different kinds of cures?\u003c/strong>\u003c/p>\n\u003cp>By my definition of a cure which is for five years now he has had no replicating virus in his body, he is not able to infect anybody and he doesn’t have to take drugs. He is cured as far as I am concerned. If you want to get into semantics, one of the things that scientists are curious about is did we manage to remove every last trace of virus from his body or does he have some bits of dead virus floating around? I guess if you look long enough and hard enough – absolutely, we would find some traces of HIV. Importantly, if we are trying to develop ways to take lessons that happened to Timothy, and develop a treatment that can be given to people without needing a bone marrow transplant, to my mind the best possible outcome is that we find that Timothy still has these little remnants of HIV but despite that he is able to control it and he has cured himself through having this HIV resistant immune system.\u003c/p>\n\u003cp>\u003cstrong>You are using funds from the California Stem Cell Bond to help with this research?\u003c/strong>\u003c/p>\n\u003cp>That’s correct, and that’s been really, really important. When we first started this sort of work, we were doing it in collaboration with a biotech company in the Bay Area. And we were able to go to the California Institute of Regenerative Medicine, which is the agency that was set up after the stem cell initiative in 2004.\u003c/p>\n\u003cp>We were able to persuade them, I think, not just that in this way we could be using stem cells to really deliver a therapy to HIV-positive people, but also that the sort of techniques that we were developing in this way are going to have applications beyond HIV.\u003c/p>\n\u003cp>\u003cstrong>One of the challenges with stem cell therapy is the high cost of research and the distant payoff for the whole thing. So you are going to start the human trials in 2014 – what are you looking at in terms of seeing some signs if some of this gene therapy is working?\u003c/strong>\u003c/p>\n\u003cp>We have a series of benchmarks that we would look for. First of all, do we see any evidence that the CCR-5 negative cells are appearing in the patients after we give them the stem cells back? Are the levels of these cells increasing, which would suggest they have a selective advantage in the body?\u003c/p>\n\u003cp>We hope, of course, to end up with the situation, as happened with Timothy, whereby we can take the patients off the drugs, and they are themselves able to suppress and control the virus. I think for me, I’m very optimistic about it, because what we’re talking about are new types of medicine – gene therapies, cellular therapies – and we certainly don’t have the processes in place to make this cheap and easy yet. But I happen to believe that that’s just an engineering problem.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>If this works, if these sort of therapies can really allow people to live without taking drugs and to cure themselves of HIV, there’s gonna be such excitement about this, such a big effort into figuring out how to do it at scale, to do it cheaply. We’re just gonna invent whole different ways of doing medicine.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/41171/a-unique-hiv-case-inspires-new-research","authors":["212"],"categories":["quest_4","quest_12"],"tags":["quest_252","quest_11306","quest_517","quest_1375","quest_11308","quest_13203","quest_11309","quest_13","quest_11307"],"featImg":"quest_41261","label":"quest"},"quest_954":{"type":"posts","id":"quest_954","meta":{"index":"posts_1591205157","site":"quest","id":"954","score":null,"sort":[1227538833000]},"guestAuthors":[],"slug":"curing-aids-with-a-bone-marrow-transplant","title":"Curing AIDS with a Bone Marrow Transplant","publishDate":1227538833,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2008/11/hiv_image.jpg\">\u003cem>People with the delta 32 version of the CCR5 gene are more\u003cbr>\nresistant to HIV infection.\u003cbr>\n\u003c/em>\u003c/span>Doctors \u003ca href=\"http://ap.google.com/article/ALeqM5hwlpMzO2z0voECw2T4MfOPkOEXNAD94DSGLG0\">announced in Berlin\u003c/a> that a man who received a bone marrow transplant for leukemia was now also free of his HIV infection. Looks like this patient's luck is finally turning around!\u003c/p>\n\u003cp>Both leukemia and AIDS are diseases of the blood. Bone marrow transplants cure leukemia by permanently replacing the patient's blood with the donor's. This eliminates the cancerous blood cells and so cures the cancer.\u003c/p>\n\u003cp>One \"side effect\" of a bone marrow transplant is that the patient's blood cells now have donor's DNA. This sometimes makes for \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=208\">problems at crime scenes\u003c/a> (and interesting CSI episodes). But here the doctor used it to the patient's advantage.\u003c/p>\n\u003cp>Scientists have known for a long time that people with two copies of a certain version of the CCR5 gene, the \u003ca href=\"http://www.thetech.org/genetics/news.php?id=13\">delta 32 version\u003c/a>, are much more resistant to HIV. Their AIDS symptoms also tend to progress much more slowly.\u003c/p>\n\u003cp>So the doctors reasoned that if the patient were going to receive a bone marrow transplant anyway, why not give him one from a donor with two copies of delta 32? And that’s just what the doctors did.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Over 20 months later, there is no sign of the patient’s leukemia. And no sign of HIV either. \u003c/p>\n\u003cp>We'll still need to wait and see if this result holds up. But even if it does, this cure isn't for everyone. It is expensive and very risky.\u003c/p>\n\u003cp>Around 1 in 4 patients dies from bone marrow transplants. I'm no M.D., but I would guess that patients at the later stages of AIDS would do even more poorly.\u003c/p>\n\u003cp>But if the result does hold up, then maybe scientists can figure out how to do something similar without the bone marrow transplant. Maybe they can find a medicine that can shut down the CCR5 gene and so get the same effects as the delta 32 version. Another possibility is gene therapy.\u003c/p>\n\u003cp>The idea would be to change the patient's CCR5 gene into the delta 32 version. This would be really hard. \u003c/p>\n\u003cp>\u003ca href=\"http://www.thetech.org/genetics/ask.php?id=260\">Gene therapy\u003c/a> is pretty good at adding a working gene to a cell. It is not very good at changing a patient's gene. This means it would not be easy to turn a CCR5 gene into the delta 32 version in a patient's bone marrow cells.\u003c/p>\n\u003cp>But maybe there is another way. The CCR5 gene is not the only way to be resistant to HIV. Another way is by having \u003ca href=\"http://www.thetech.org/genetics/news.php?id=38\">extra copies of the CCL3L1 gene\u003c/a>. Perhaps scientists could add extra copies of this gene to a patient's bone marrow cells and help at least slow down HIV. This seems doable with gene therapy. \u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.332 -121.903\u003c/p>\n\n","blocks":[],"excerpt":"Doctors announced in Berlin that a man who received a bone marrow transplant for leukemia was now also free of his HIV infection.","status":"publish","parent":0,"modified":1227538833,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":15,"wordCount":476},"headData":{"title":"Curing AIDS with a Bone Marrow Transplant | KQED","description":"Doctors announced in Berlin that a man who received a bone marrow transplant for leukemia was now also free of his HIV infection.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Curing AIDS with a Bone Marrow Transplant","datePublished":"2008-11-24T15:00:33.000Z","dateModified":"2008-11-24T15:00:33.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"954 http://www.kqed.org/quest/blog/?p=954","disqusUrl":"https://ww2.kqed.org/quest/2008/11/24/curing-aids-with-a-bone-marrow-transplant/","disqusTitle":"Curing AIDS with a Bone Marrow Transplant","path":"/quest/954/curing-aids-with-a-bone-marrow-transplant","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2008/11/hiv_image.jpg\">\u003cem>People with the delta 32 version of the CCR5 gene are more\u003cbr>\nresistant to HIV infection.\u003cbr>\n\u003c/em>\u003c/span>Doctors \u003ca href=\"http://ap.google.com/article/ALeqM5hwlpMzO2z0voECw2T4MfOPkOEXNAD94DSGLG0\">announced in Berlin\u003c/a> that a man who received a bone marrow transplant for leukemia was now also free of his HIV infection. Looks like this patient's luck is finally turning around!\u003c/p>\n\u003cp>Both leukemia and AIDS are diseases of the blood. Bone marrow transplants cure leukemia by permanently replacing the patient's blood with the donor's. This eliminates the cancerous blood cells and so cures the cancer.\u003c/p>\n\u003cp>One \"side effect\" of a bone marrow transplant is that the patient's blood cells now have donor's DNA. This sometimes makes for \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=208\">problems at crime scenes\u003c/a> (and interesting CSI episodes). But here the doctor used it to the patient's advantage.\u003c/p>\n\u003cp>Scientists have known for a long time that people with two copies of a certain version of the CCR5 gene, the \u003ca href=\"http://www.thetech.org/genetics/news.php?id=13\">delta 32 version\u003c/a>, are much more resistant to HIV. Their AIDS symptoms also tend to progress much more slowly.\u003c/p>\n\u003cp>So the doctors reasoned that if the patient were going to receive a bone marrow transplant anyway, why not give him one from a donor with two copies of delta 32? And that’s just what the doctors did.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Over 20 months later, there is no sign of the patient’s leukemia. And no sign of HIV either. \u003c/p>\n\u003cp>We'll still need to wait and see if this result holds up. But even if it does, this cure isn't for everyone. It is expensive and very risky.\u003c/p>\n\u003cp>Around 1 in 4 patients dies from bone marrow transplants. I'm no M.D., but I would guess that patients at the later stages of AIDS would do even more poorly.\u003c/p>\n\u003cp>But if the result does hold up, then maybe scientists can figure out how to do something similar without the bone marrow transplant. Maybe they can find a medicine that can shut down the CCR5 gene and so get the same effects as the delta 32 version. Another possibility is gene therapy.\u003c/p>\n\u003cp>The idea would be to change the patient's CCR5 gene into the delta 32 version. This would be really hard. \u003c/p>\n\u003cp>\u003ca href=\"http://www.thetech.org/genetics/ask.php?id=260\">Gene therapy\u003c/a> is pretty good at adding a working gene to a cell. It is not very good at changing a patient's gene. This means it would not be easy to turn a CCR5 gene into the delta 32 version in a patient's bone marrow cells.\u003c/p>\n\u003cp>But maybe there is another way. The CCR5 gene is not the only way to be resistant to HIV. Another way is by having \u003ca href=\"http://www.thetech.org/genetics/news.php?id=38\">extra copies of the CCL3L1 gene\u003c/a>. Perhaps scientists could add extra copies of this gene to a patient's bone marrow cells and help at least slow down HIV. This seems doable with gene therapy. \u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.332 -121.903\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/954/curing-aids-with-a-bone-marrow-transplant","authors":["6177"],"categories":["quest_4","quest_12"],"tags":["quest_89","quest_362","quest_517","quest_798","quest_848","quest_1197","quest_1375","quest_1649"],"label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. 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Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.","airtime":"SUN 2pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Possible-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.possible.fm/","meta":{"site":"news","source":"Possible"},"link":"/radio/program/possible","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/possible/id1677184070","spotify":"https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"}},"1a":{"id":"1a","title":"1A","info":"1A is home to the national conversation. 1A brings on great guests and frames the best debate in ways that make you think, share and engage.","airtime":"MON-THU 11pm-12am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/1a.jpg","officialWebsiteLink":"https://the1a.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/1a","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=1188724250&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/1A-p947376/","rss":"https://feeds.npr.org/510316/podcast.xml"}},"all-things-considered":{"id":"all-things-considered","title":"All Things Considered","info":"Every weekday, \u003cem>All Things Considered\u003c/em> hosts Robert Siegel, Audie Cornish, Ari Shapiro, and Kelly McEvers present the program's trademark mix of news, interviews, commentaries, reviews, and offbeat features. 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But is this once sleepy suburb ready for them?","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/American-Suburb-Podcast-Tile-703x703-1.jpg","officialWebsiteLink":"/news/series/american-suburb-podcast","meta":{"site":"news","source":"kqed","order":"13"},"link":"/news/series/american-suburb-podcast/","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?mt=2&id=1287748328","tuneIn":"https://tunein.com/radio/American-Suburb-p1086805/","rss":"https://ww2.kqed.org/news/series/american-suburb-podcast/feed/podcast","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkMzMDExODgxNjA5"}},"baycurious":{"id":"baycurious","title":"Bay Curious","tagline":"Exploring the Bay Area, one question at a time","info":"KQED’s new podcast, Bay Curious, gets to the bottom of the mysteries — both profound and peculiar — that give the Bay Area its unique identity. And we’ll do it with your help! You ask the questions. You decide what Bay Curious investigates. 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Hosts Steve Inskeep, David Greene and Rachel Martin bring you the latest breaking news and features to prepare you for the day.","airtime":"MON-FRI 3am-9am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Morning-Edition-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/morning-edition/","meta":{"site":"news","source":"npr"},"link":"/radio/program/morning-edition"},"onourwatch":{"id":"onourwatch","title":"On Our Watch","tagline":"Police secrets, unsealed","info":"For decades, the process for how police police themselves has been inconsistent – if not opaque. In some states, like California, these proceedings were completely hidden. After a new police transparency law unsealed scores of internal affairs files, our reporters set out to examine these cases and the shadow world of police discipline. On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. Is it the officers, or the public they've sworn to serve?","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/On-Our-Watch-Podcast-Tile-703x703-1.jpg","imageAlt":"On Our Watch from NPR and KQED","officialWebsiteLink":"/podcasts/onourwatch","meta":{"site":"news","source":"kqed","order":"1"},"link":"/podcasts/onourwatch","subscribe":{"apple":"https://podcasts.apple.com/podcast/id1567098962","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5ucHIub3JnLzUxMDM2MC9wb2RjYXN0LnhtbD9zYz1nb29nbGVwb2RjYXN0cw","npr":"https://rpb3r.app.goo.gl/onourwatch","spotify":"https://open.spotify.com/show/0OLWoyizopu6tY1XiuX70x","tuneIn":"https://tunein.com/radio/On-Our-Watch-p1436229/","stitcher":"https://www.stitcher.com/show/on-our-watch","rss":"https://feeds.npr.org/510360/podcast.xml"}},"on-the-media":{"id":"on-the-media","title":"On The Media","info":"Our weekly podcast explores how the media 'sausage' is made, casts an incisive eye on fluctuations in the marketplace of ideas, and examines threats to the freedom of information and expression in America and abroad. For one hour a week, the show tries to lift the veil from the process of \"making media,\" especially news media, because it's through that lens that we see the world and the world sees us","airtime":"SUN 2pm-3pm, MON 12am-1am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/onTheMedia.png","officialWebsiteLink":"https://www.wnycstudios.org/shows/otm","meta":{"site":"news","source":"wnyc"},"link":"/radio/program/on-the-media","subscribe":{"apple":"https://itunes.apple.com/us/podcast/on-the-media/id73330715?mt=2","tuneIn":"https://tunein.com/radio/On-the-Media-p69/","rss":"http://feeds.wnyc.org/onthemedia"}},"our-body-politic":{"id":"our-body-politic","title":"Our Body Politic","info":"Presented by KQED, KCRW and KPCC, and created and hosted by award-winning journalist Farai Chideya, Our Body Politic is unapologetically centered on reporting on not just how women of color experience the major political events of today, but how they’re impacting those very issues.","airtime":"SAT 6pm-7pm, SUN 1am-2am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Our-Body-Politic-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://our-body-politic.simplecast.com/","meta":{"site":"news","source":"kcrw"},"link":"/radio/program/our-body-politic","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/our-body-politic/id1533069868","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5zaW1wbGVjYXN0LmNvbS9feGFQaHMxcw","spotify":"https://open.spotify.com/show/4ApAiLT1kV153TttWAmqmc","rss":"https://feeds.simplecast.com/_xaPhs1s","tuneIn":"https://tunein.com/podcasts/News--Politics-Podcasts/Our-Body-Politic-p1369211/"}},"pbs-newshour":{"id":"pbs-newshour","title":"PBS NewsHour","info":"Analysis, background reports and updates from the PBS NewsHour putting today's news in context.","airtime":"MON-FRI 3pm-4pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/PBS-News-Hour-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.pbs.org/newshour/","meta":{"site":"news","source":"pbs"},"link":"/radio/program/pbs-newshour","subscribe":{"apple":"https://itunes.apple.com/us/podcast/pbs-newshour-full-show/id394432287?mt=2","tuneIn":"https://tunein.com/radio/PBS-NewsHour---Full-Show-p425698/","rss":"https://www.pbs.org/newshour/feeds/rss/podcasts/show"}},"perspectives":{"id":"perspectives","title":"Perspectives","tagline":"KQED's series of of daily listener commentaries since 1991","info":"KQED's series of of daily listener commentaries since 1991.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Perspectives-Podcast-Tile-703x703-1.jpg","officialWebsiteLink":"/perspectives/","meta":{"site":"radio","source":"kqed","order":"15"},"link":"/perspectives","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/id73801135","npr":"https://www.npr.org/podcasts/432309616/perspectives","rss":"https://ww2.kqed.org/perspectives/category/perspectives/feed/","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93dzIua3FlZC5vcmcvcGVyc3BlY3RpdmVzL2NhdGVnb3J5L3BlcnNwZWN0aXZlcy9mZWVkLw"}},"planet-money":{"id":"planet-money","title":"Planet Money","info":"The economy explained. 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