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	<title>KQED QUEST &#187; bottleneck</title>
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		<title>Explosive hypothesis about humans&#039; lack of genetic diversity</title>
		<link>http://science.kqed.org/quest/2008/03/17/explosive-hypothesis-about-humans-lack-of-genetic-diversity/</link>
		<comments>http://science.kqed.org/quest/2008/03/17/explosive-hypothesis-about-humans-lack-of-genetic-diversity/#comments</comments>
		<pubDate>Mon, 17 Mar 2008 17:59:41 +0000</pubDate>
		<dc:creator>Dr. Barry Starr</dc:creator>
				<category><![CDATA[Climate]]></category>
		<category><![CDATA[Environment]]></category>
		<category><![CDATA[Geology]]></category>
		<category><![CDATA[Partners]]></category>
		<category><![CDATA[bottleneck]]></category>
		<category><![CDATA[eruption]]></category>
		<category><![CDATA[evolution]]></category>
		<category><![CDATA[genetics]]></category>
		<category><![CDATA[kqed]]></category>
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		<category><![CDATA[QUEST]]></category>
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		<category><![CDATA[toba]]></category>
		<category><![CDATA[volcano]]></category>

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		<description><![CDATA[Genetically, we're all pretty much the same. A massive volcanic eruption 75,000 years ago may be why. Lake Toba is all that is left of the volcano that nearly wiped out mankind.Last blog I talked about how East Africans are genetically more diverse than Asians. Who are genetically more diverse than Native Americans. From all [...]]]></description>
			<content:encoded><![CDATA[<p><strong>Genetically, we're all pretty much the same. A massive volcanic eruption 75,000 years ago may be why.</strong></p>
<p><span class="left"><img src="http://science.kqed.org/quest/files/2008/03/lake-toba.jpg" /><em>Lake Toba is all that is left of the volcano<br />
that nearly wiped out mankind.</em></span><a href="http://science.kqed.org/quest/2008/03/03/tracing-the-travels-of-the-human-race/">Last blog</a> I talked about how East Africans are genetically more diverse than Asians.  Who are genetically more diverse than Native Americans.</p>
<p>From all of this you might have concluded that people are pretty different from each other.  They aren't.</p>
<p>People are surprisingly similar at a genetic level.  For example, any two people from anywhere on Earth are more similar than two chimps from the <em>same</em> troop.  Why are we all so alike?</p>
<p>One possible explanation is that something in our collective past nearly wiped us all out.  And we all come from the few survivors who were left.</p>
<p>A likely candidate for this near annihilation event is the <a href="http://volcano.und.edu/vwdocs/volc_images/southeast_asia/indonesia/toba.html">Toba volcanic eruption</a> that happened in Indonesia 75,000 or so years ago.  This eruption was huge.</p>
<p>It was equivalent to around 1 billion tons of dynamite and was about 3000 times more powerful than the Mount Saint Helens eruption in 1980.  It also may have reduced the average global temperature by 5 degrees Celsius, darkened the world for 5 or 6 years, and plunged the world into a new Ice Age.</p>
<p>As you might imagine, this eruption had dramatic effects on species around the world including our own.  Estimates of how many people were left range from around 1000-10,000 breeding pairs.  The theory is that we are all so alike because we share these survivors' DNA.</p>
<p>Whether true or not, a bottleneck in our past would not make us unique.  Lots of species go through these near death experiences.</p>
<p>Scientists think cheetahs went through one around 10,000 years ago.  Cheetahs are all so similar genetically that veterinarians can do skin grafts with "unrelated" cheetahs.</p>
<p>And of course, people have created bottlenecks in species too.  For example, in the late 1890's there may have only been 20-100 elephant seals left in the world because of hunting.  Now there are at least 150,000 spread across the west coast.</p>
<p><a href="http://www.thetech.org/genetics/ask.php?id=113">Species are in danger</a> long after they go through a bottleneck. They have a pretty limited gene pool which means they may not be particularly healthy and are in danger of being wiped out by, for example, a single disease.  Humans are probably OK in this regard (consider <a href="http://www.thetech.org/genetics/news.php?id=13">natural resistance to HIV</a> for example) but elephant seals, bison, and cheetahs, and many other species may not be.</p>
<p>Fortunately for us we successfully came through our bottleneck.  Hopefully, the animals that we've nearly wiped out will too.</p>
<p><span class="left"><img src="http://science.kqed.org/quest/files/imp/icon_barry.jpg" /></span><em><strong>Dr. Barry Starr</strong> is a Geneticist-in-Residence at <a href="http://www.thetech.org">The Tech Museum of Innovation</a> in San Jose, CA.</em><br />
<br clear="all" /></p>

	Tags: <a href="http://science.kqed.org/quest/tag/bottleneck/" title="bottleneck" rel="tag">bottleneck</a>, <a href="http://science.kqed.org/quest/tag/eruption/" title="eruption" rel="tag">eruption</a>, <a href="http://science.kqed.org/quest/tag/evolution/" title="evolution" rel="tag">evolution</a>, <a href="http://science.kqed.org/quest/tag/genetics/" title="genetics" rel="tag">genetics</a>, <a href="http://science.kqed.org/quest/tag/kqed/" title="kqed" rel="tag">kqed</a>, <a href="http://science.kqed.org/quest/tag/kqedquest/" title="kqedquest" rel="tag">kqedquest</a>, <a href="http://science.kqed.org/quest/tag/quest/" title="QUEST" rel="tag">QUEST</a>, <a href="http://science.kqed.org/quest/tag/techmuseum/" title="techmuseum" rel="tag">techmuseum</a>, <a href="http://science.kqed.org/quest/tag/toba/" title="toba" rel="tag">toba</a>, <a href="http://science.kqed.org/quest/tag/volcano/" title="volcano" rel="tag">volcano</a><br />
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